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学科主题临床医学
Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease
He, Li-Yun1,2; Zhao, Jun-Feng3; Han, Jiang-Li1,2; Shen, Shan-Shan4; Chen, Xu-Jiao4
关键词Coronary heart disease Free fatty acids Gensini score The elderly
刊名JOURNAL OF GERIATRIC CARDIOLOGY
2014
DOI10.3969/j.issn.1671-5411.2014.01.003
11期:1页:57-62
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]TUMOR-NECROSIS-FACTOR ; ARTERY-DISEASE ; ENDOTHELIAL DYSFUNCTION ; STIMULATES LIPOLYSIS ; METABOLIC SYNDROME ; OXIDATIVE STRESS ; ATHEROSCLEROSIS ; SEVERITY ; CELLS ; HOMOCYSTEINE
英文摘要

Objectives To investigate the relationship between serum free fatty acids (FFAs) levels and the severity of coronary artery lesions in elderly patients with coronary heart disease (CAD).

Methods A total of 172 elderly patients who underwent coronary angiography were divided into CAD group (n = 128) and non-CAD group (n = 44) according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated.

Results No matter the differences between age, gender and the usage of statins or not, there was no statistical significance in FFAs levels (P > 0.05). In terms of the Gensini score, it was higher in patients aged 70-79 years than in patients 60-69 years old [ 15.00 (5.00, 34.00) vs. 10.00 (2.00, 24.00), P < 0.05], higher in men than women [ 14.00 (4.00, 34.00) vs. 7.00 (2.50, 19.75), P < 0.05], and higher in patients on statins [ 13.50 (4.25, 33.50) vs. 6.50 (2.00, 18.00), P < 0.05]. The serum FFAs levels [ 449.50 (299.00, 624.75) mEq/L vs. 388.00 (258.50, 495.25) mEq/L, P < 0.05] and Gensini score [ 17.50 (8.00, 41.75) vs. 1.00 (0, 5.00), P < 0.05] were higher in the CAD group than in the non-CAD group. In the CAD group, there was no statistical significance in FFAs levels among patients with different numbers of diseased coronary vessels (P > 0.05). Furthermore, the FFAs levels were positively correlated with the Gensini score (r = 0.394, P = 0.005). Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors.

Conclusions The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.

语种英语
WOS记录号WOS:000334078700009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64696
专题北京大学第三临床医学院_心血管内科
作者单位1.Zhejiang Hosp, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
4.Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Emergency, Hangzhou 310005, Zhejiang, Peoples R China
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GB/T 7714
He, Li-Yun,Zhao, Jun-Feng,Han, Jiang-Li,et al. Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2014,11(1):57-62.
APA He, Li-Yun,Zhao, Jun-Feng,Han, Jiang-Li,Shen, Shan-Shan,&Chen, Xu-Jiao.(2014).Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease.JOURNAL OF GERIATRIC CARDIOLOGY,11(1),57-62.
MLA He, Li-Yun,et al."Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease".JOURNAL OF GERIATRIC CARDIOLOGY 11.1(2014):57-62.
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