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学科主题: 临床医学
题名:
Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease
作者: He, Li-Yun1,2; Zhao, Jun-Feng3; Han, Jiang-Li1,2; Shen, Shan-Shan4; Chen, Xu-Jiao4
关键词: Coronary heart disease ; Free fatty acids ; Gensini score ; The elderly
刊名: JOURNAL OF GERIATRIC CARDIOLOGY
发表日期: 2014
DOI: 10.3969/j.issn.1671-5411.2014.01.003
卷: 11, 期:1, 页:57-62
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
研究领域[WOS]: Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; ARTERY-DISEASE ; ENDOTHELIAL DYSFUNCTION ; STIMULATES LIPOLYSIS ; METABOLIC SYNDROME ; OXIDATIVE STRESS ; ATHEROSCLEROSIS ; SEVERITY ; CELLS ; HOMOCYSTEINE
英文摘要:

Objectives To investigate the relationship between serum free fatty acids (FFAs) levels and the severity of coronary artery lesions in elderly patients with coronary heart disease (CAD).

Methods A total of 172 elderly patients who underwent coronary angiography were divided into CAD group (n = 128) and non-CAD group (n = 44) according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated.

Results No matter the differences between age, gender and the usage of statins or not, there was no statistical significance in FFAs levels (P > 0.05). In terms of the Gensini score, it was higher in patients aged 70-79 years than in patients 60-69 years old [ 15.00 (5.00, 34.00) vs. 10.00 (2.00, 24.00), P < 0.05], higher in men than women [ 14.00 (4.00, 34.00) vs. 7.00 (2.50, 19.75), P < 0.05], and higher in patients on statins [ 13.50 (4.25, 33.50) vs. 6.50 (2.00, 18.00), P < 0.05]. The serum FFAs levels [ 449.50 (299.00, 624.75) mEq/L vs. 388.00 (258.50, 495.25) mEq/L, P < 0.05] and Gensini score [ 17.50 (8.00, 41.75) vs. 1.00 (0, 5.00), P < 0.05] were higher in the CAD group than in the non-CAD group. In the CAD group, there was no statistical significance in FFAs levels among patients with different numbers of diseased coronary vessels (P > 0.05). Furthermore, the FFAs levels were positively correlated with the Gensini score (r = 0.394, P = 0.005). Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors.

Conclusions The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.

语种: 英语
WOS记录号: WOS:000334078700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64696
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Zhejiang Hosp, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
4.Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Emergency, Hangzhou 310005, Zhejiang, Peoples R China

Recommended Citation:
He, Li-Yun,Zhao, Jun-Feng,Han, Jiang-Li,et al. Correlation between serum free fatty acids levels and Gensini score in elderly patients with coronary heart disease[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2014,11(1):57-62.
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