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Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice
Yang, Ruiyue1,2,3; Pei, Xinrong1,4; Wang, Junbo1; Zhang, Zhaofeng1; Zhao, Haifeng1; Li, Qiong1; Zhao, Ming1; Li, Yong1
关键词bioactive peptide radioprotective immunosuppression T-cell subpopulation cytokine nuclear factor kappa B
刊名JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
2010-10-01
DOI10.1002/jsfa.4077
90期:13页:2241-2248
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]BONE-MARROW-CELLS ; FACTOR-KAPPA-B ; IONIZING-RADIATION ; BIOACTIVE PEPTIDES ; ULTRAVIOLET-RADIATION ; CYTOKINE ; FOOD ; EXPRESSION ; RESPONSES ; RECOVERY
英文摘要

BACKGROUND: A marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to enhance the innate and adaptive immunities through stimulation of the secretion of cytokines in mice. The current study aimed to further investigate the protective effect of MOP on radiation-induced immune suppression in mice.

RESULTS: Female ICR mice (6-8 weeks old) were randomly divided into three groups, i.e. blank control, irradiation control and MOP(1.350 g kg(-1) body weight) plus irradiation-treated group. MOP significantly increased the survival rate and prolonged the survival times for 30 days after irradiation, and lessened the radiation-induced suppression of T-or B-lymphocyte proliferation, resulting in the recovery of cell-mediated and humoral immune functions. This effect may be produced by augmentation of the relative numbers of radioresistant CD(4)(+) T cells, enhancement of the level of immunostimulatory cytokine, IL-12, reduction of the level of total cellular NF-kappa B through the induction of I kappa B in spleen and inhibition of the apoptosis of splenocytes.

CONCLUSION: We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation-induced injuries in cancer patients. (C) 2010 Society of Chemical Industry

语种英语
WOS记录号WOS:000282667500014
项目编号2006BAD27B08
资助机构Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64698
专题北京大学公共卫生学院
作者单位1.Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
2.Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
4.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing 100069, Peoples R China
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GB/T 7714
Yang, Ruiyue,Pei, Xinrong,Wang, Junbo,et al. Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice[J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,2010,90(13):2241-2248.
APA Yang, Ruiyue.,Pei, Xinrong.,Wang, Junbo.,Zhang, Zhaofeng.,Zhao, Haifeng.,...&Li, Yong.(2010).Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice.JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,90(13),2241-2248.
MLA Yang, Ruiyue,et al."Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice".JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 90.13(2010):2241-2248.
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