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学科主题: 公共卫生
题名:
Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice
作者: Yang, Ruiyue1,2,3; Pei, Xinrong1,4; Wang, Junbo1; Zhang, Zhaofeng1; Zhao, Haifeng1; Li, Qiong1; Zhao, Ming1; Li, Yong1
关键词: bioactive peptide ; radioprotective ; immunosuppression ; T-cell subpopulation ; cytokine ; nuclear factor kappa B
刊名: JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
发表日期: 2010-10-01
DOI: 10.1002/jsfa.4077
卷: 90, 期:13, 页:2241-2248
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]: BONE-MARROW-CELLS ; FACTOR-KAPPA-B ; IONIZING-RADIATION ; BIOACTIVE PEPTIDES ; ULTRAVIOLET-RADIATION ; CYTOKINE ; FOOD ; EXPRESSION ; RESPONSES ; RECOVERY
英文摘要:

BACKGROUND: A marine oligopeptide preparation (MOP) obtained from Chum Salmon (Oncorhynchus keta) by the method of enzymatic hydrolysis, has been found to enhance the innate and adaptive immunities through stimulation of the secretion of cytokines in mice. The current study aimed to further investigate the protective effect of MOP on radiation-induced immune suppression in mice.

RESULTS: Female ICR mice (6-8 weeks old) were randomly divided into three groups, i.e. blank control, irradiation control and MOP(1.350 g kg(-1) body weight) plus irradiation-treated group. MOP significantly increased the survival rate and prolonged the survival times for 30 days after irradiation, and lessened the radiation-induced suppression of T-or B-lymphocyte proliferation, resulting in the recovery of cell-mediated and humoral immune functions. This effect may be produced by augmentation of the relative numbers of radioresistant CD(4)(+) T cells, enhancement of the level of immunostimulatory cytokine, IL-12, reduction of the level of total cellular NF-kappa B through the induction of I kappa B in spleen and inhibition of the apoptosis of splenocytes.

CONCLUSION: We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation-induced injuries in cancer patients. (C) 2010 Society of Chemical Industry

语种: 英语
所属项目编号: 2006BAD27B08
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000282667500014
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64698
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China
2.Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
4.Capital Med Univ, Ctr Food & Drug Safety Evaluat, Beijing 100069, Peoples R China

Recommended Citation:
Yang, Ruiyue,Pei, Xinrong,Wang, Junbo,et al. Protective effect of a marine oligopeptide preparation from Chum Salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice[J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,2010,90(13):2241-2248.
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