IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition
Chen, Tianda1,2,3; Wu, Qinwei4,5; Zhang, Yang1,2,3; Zhang, Dai1,2,3,5,6
关键词Developing cerebral cortex Neuronal migration In utero Electroporation NDUFV2
刊名BRAIN RESEARCH
2015-11-02
DOI10.1016/j.brainres.2015.08.028
1625页:102-110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MITOCHONDRIAL COMPLEX-I ; SUBUNIT GENE NDUFV2 ; PARKINSONS-DISEASE ; LYMPHOBLASTOID-CELLS ; SCHIZOPHRENIA ; DISORDER ; ASSOCIATION ; EXPRESSION ; 18P11 ; CARDIOMYOPATHY
英文摘要

Abnormalities during brain development are tightly linked several psychiatric disorders. Mutations in NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) are responsible for schizophrenia, bipolar disorder and Parkinson′s disease. However, the function of NDUFV2 during brain development remains unclear. Here we reported that ndufu2 is expressed in the developing cerebral cortex. In utero suppression of ndufu2 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. ndufu2 inhibition did not affect radial glia scaffold, progenitor cells or neurons survival. However, the loss of ndufu2 impairs neuronal multipolar-bipolar transition in vivo and polarization in vitro. Moreover, ndufu2 affected actin cytoskeleton and tubulin stabilization in cortical neurons. Overall, our findings establish a new NDUFV2 dependent mechanism underlying neuronal migration and psychiatric disorders. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000365052000011
项目编号81401111 ; 7144259 ; 20130001120115
资助机构National Natural Science Foundation of China ; Bejing Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64704
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100191, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Tianda,Wu, Qinwei,Zhang, Yang,et al. NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition[J]. BRAIN RESEARCH,2015,1625:102-110.
APA Chen, Tianda,Wu, Qinwei,Zhang, Yang,&Zhang, Dai.(2015).NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.BRAIN RESEARCH,1625,102-110.
MLA Chen, Tianda,et al."NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition".BRAIN RESEARCH 1625(2015):102-110.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Tianda]的文章
[Wu, Qinwei]的文章
[Zhang, Yang]的文章
百度学术
百度学术中相似的文章
[Chen, Tianda]的文章
[Wu, Qinwei]的文章
[Zhang, Yang]的文章
必应学术
必应学术中相似的文章
[Chen, Tianda]的文章
[Wu, Qinwei]的文章
[Zhang, Yang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。