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学科主题: 精神卫生
题名:
NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition
作者: Chen, Tianda1,2,3; Wu, Qinwei4,5; Zhang, Yang1,2,3; Zhang, Dai1,2,3,5,6
关键词: Developing cerebral cortex ; Neuronal migration ; In utero Electroporation ; NDUFV2
刊名: BRAIN RESEARCH
发表日期: 2015-11-02
DOI: 10.1016/j.brainres.2015.08.028
卷: 1625, 页:102-110
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MITOCHONDRIAL COMPLEX-I ; SUBUNIT GENE NDUFV2 ; PARKINSONS-DISEASE ; LYMPHOBLASTOID-CELLS ; SCHIZOPHRENIA ; DISORDER ; ASSOCIATION ; EXPRESSION ; 18P11 ; CARDIOMYOPATHY
英文摘要:

Abnormalities during brain development are tightly linked several psychiatric disorders. Mutations in NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) are responsible for schizophrenia, bipolar disorder and Parkinson′s disease. However, the function of NDUFV2 during brain development remains unclear. Here we reported that ndufu2 is expressed in the developing cerebral cortex. In utero suppression of ndufu2 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. ndufu2 inhibition did not affect radial glia scaffold, progenitor cells or neurons survival. However, the loss of ndufu2 impairs neuronal multipolar-bipolar transition in vivo and polarization in vitro. Moreover, ndufu2 affected actin cytoskeleton and tubulin stabilization in cortical neurons. Overall, our findings establish a new NDUFV2 dependent mechanism underlying neuronal migration and psychiatric disorders. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81401111 ; 7144259 ; 20130001120115
项目资助者: National Natural Science Foundation of China ; Bejing Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000365052000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64704
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100191, Peoples R China
5.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100191, Peoples R China
6.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Tianda,Wu, Qinwei,Zhang, Yang,et al. NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition[J]. BRAIN RESEARCH,2015,1625:102-110.
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