IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations
Wang, Shu-Mei1; Zhu, An-Ping2; Li, Dan1; Wang, Zhen2; Zhang, Ping2; Zhang, Guo-Liang1
关键词CYP2C19 CYP2E1 genetic polymorphisms Han Kazakh mainland Chinese Uygur
刊名JOURNAL OF HUMAN GENETICS
2009-06-01
DOI10.1038/jhg.2009.41
54期:6页:372-375
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Genetics & Heredity
关键词[WOS]GENETIC POLYMORPHISMS ; METABOLIZING-ENZYMES ; CYP3A5 ; POOR ; 2C19
英文摘要

CYP2C19 and CYP2E1 show great genetic differences between Orientals and Caucasians. The objective of this study was to investigate the genotype and allele distribution patterns of CYP2C19 and CYP2E1 polymorphisms among healthy participants in mainland Chinese Kazakh, Uygur and Han populations by the PCR-restriction fragment length polymorphism technique. The allele frequencies of CYP2C19*2, CYP2E1*5B and CYP2E1*6 were significantly lower in the Chinese Kazakh (15.4, 11.2 and 14.5%, respectively) (P < 0.05) and Uygur (16.1, 12.1 and 18.8%) (P < 0.05) populations than that in the Chinese Han population (28.8, 19.4 and 26.2%), but the frequencies of CYP2C19*3 were similar among the three populations (8.0, 9.4 and 7.2%). Frequencies of the three combined genotypes, one for predicted CYP2C19 poor metabolizers and two for predicted high levels of CYP2E1 transcription, were significantly lower in the Chinese Kazakh (7.5, 19.6 and 28.0%, respectively) (P < 0.05, chi(2)-test) and Uygur (8.1, 22.8 and 33.6%) (P < 0.05) populations compared with the Chinese Han population (16.5, 35.9 and 44.7%). The present research shows that frequencies of the functional single-nucleotide polymorphisms in the CYP2C19 and CYP2E1 genes vary in the Chinese Kazakh, Uygur and Han populations, suggesting that disease susceptibilities or drug responses associated with enzyme activities of CYP2C19 and CYP2E1 may differ in the diverse ethnic populations in mainland China. Journal of Human Genetics (2009) 54, 372-375; doi:10.1038/jhg.2009.41; published online 15 May 2009

语种英语
所属项目编号30171097 ; 30371665
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000268312700012
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64708
Collection北京大学基础医学院_药理学系
作者单位1.Beijing Univ, Dept Pharmacol, Basic Med Sch, Beijing 100191, Peoples R China
2.Cent Univ Nationalities, Affiliated Hosp, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shu-Mei,Zhu, An-Ping,Li, Dan,et al. Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations[J]. JOURNAL OF HUMAN GENETICS,2009,54(6):372-375.
APA Wang, Shu-Mei,Zhu, An-Ping,Li, Dan,Wang, Zhen,Zhang, Ping,&Zhang, Guo-Liang.(2009).Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations.JOURNAL OF HUMAN GENETICS,54(6),372-375.
MLA Wang, Shu-Mei,et al."Frequencies of genotypes and alleles of the functional SNPs in CYP2C19 and CYP2E1 in mainland Chinese Kazakh, Uygur and Han populations".JOURNAL OF HUMAN GENETICS 54.6(2009):372-375.
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