IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
The relaxing ori-ter balance of Mycoplasma genomes
Zheng Xin1; Liu ShuLin1,2
关键词Z curve Mycoplasma genome balance ori and ter evolution
刊名SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2008-02-01
DOI10.1007/s11427-008-0017-9
51期:2页:182-189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]ESCHERICHIA-COLI K-12 ; SALMONELLA-ENTERICA ; REPLICATION ORIGINS ; SEQUENCE ; TYPHI ; CHROMOSOME ; PATHOGEN ; ARCHAEON ; STRAIN ; IDENTIFICATION
英文摘要

Mycoplasma are wall-less bacteria with small genomes, which are thought to have resulted from massive genome reductive processes, during which the ori-ter balance may be disrupted. For technical difficulties, ori and ter have been located only in a few Mycoplasma strains. Using the Z curve method, we were able to locate turning points on the Mycoplasma genomes, with the minimum and maximum points co-locating with ori or ter in the reference genomes. Assuming Z curve correctly located ori and ter, we calculated the distances from ori to ter in both directions on the circular genome and calculated the ori-ter balance status. The Mycoplasma genomes were not balanced, possibly as a result of close association of Mycoplasma with hosts, where there would be no other microbes for Mycoplasma to compete with for nutrients, so fastest possible growth related to balanced genomes might not be needed by Mycoplasma, leading to a relaxing ori-ter balance.

语种英语
WOS记录号WOS:000252876000012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64712
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
2.Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada
Recommended Citation
GB/T 7714
Zheng Xin,Liu ShuLin. The relaxing ori-ter balance of Mycoplasma genomes[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2008,51(2):182-189.
APA Zheng Xin,&Liu ShuLin.(2008).The relaxing ori-ter balance of Mycoplasma genomes.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,51(2),182-189.
MLA Zheng Xin,et al."The relaxing ori-ter balance of Mycoplasma genomes".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 51.2(2008):182-189.
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