IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C
Wu, Li-Yuan1; Liu, Shuhong1; Liu, Yuan1; Guo, Chaonan1; Li, Hanwei2; Li, Wenshu3; Jin, Xueyuan4; Zhang, Keming5; Zhao, Ping4; Wei, Lai6; Zhao, Jingmin1
关键词Interleukin-22 Hepatitis C virus Liver fibrosis Hepatic stellate cell
刊名CLINICAL IMMUNOLOGY
2015-05-01
DOI10.1016/j.clim.2015.03.003
158期:1页:77-87
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]B-VIRUS INFECTION ; TH17 CELLS ; DISEASE PROGRESSION ; VIRAL-HEPATITIS ; IMMUNE-RESPONSE ; SEVERITY ; IL-22 ; STAT3 ; MICE ; INFLAMMATION
英文摘要

Interleukin-22 (IL-22) is known to play a critical role in liver immunity. However, the role of IL-22 in HCV-associated liver fibrosis is poorly understood. In this study, patients with HCV infection disclosed significant increases in peripheral numbers of IL-22-producing cells as well as in IL-22 plasma levels. In the liver, the increased intrahepatic IL-22(+) cells were positively correlated with fibrotic staging scores and clinical progression from CHC to cirrhosis. Moreover, the majority of IL-22 cells were located in fibrotic areas in the liver of patients with cirrhosis and co-localized with alpha-smooth muscle actin (alpha-SMA) positive hepatic stellate cells (HSCs). In vitro, administration of IL-22 was accompanied with inhibited LX-2 cell apoptosis, promoted LX-2 cell proliferation, increased expression of alpha-SMA, and up-regulated collagen production by LX-2 cells. Collectively, our data provide evidence that IL-22 may contribute to the fibrogenesis of HCV-associated liver fibrosis by activating HSCs. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000354592600009
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64717
专题北京大学第二临床医学院
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Beijing 302 Hosp, Ctr Clin Trial, Beijing 100039, Peoples R China
2.Beijing 302 Hosp, Dept Pathol & Hepatol, Beijing 100039, Peoples R China
3.Beijing 302 Hosp, Liver Cirrhosis Diag & Treatment Ctr, Beijing 100039, Peoples R China
4.Beijing 302 Hosp, Int Ctr Liver Dis Diag & Treatment, Beijing 100039, Peoples R China
5.Beijing 302 Hosp, Dept Hepatobiliary Surg, Beijing 100039, Peoples R China
6.Peking Univ, Peoples Hosp, Liver Dis Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wu, Li-Yuan,Liu, Shuhong,Liu, Yuan,et al. Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C[J]. CLINICAL IMMUNOLOGY,2015,158(1):77-87.
APA Wu, Li-Yuan.,Liu, Shuhong.,Liu, Yuan.,Guo, Chaonan.,Li, Hanwei.,...&Zhao, Jingmin.(2015).Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C.CLINICAL IMMUNOLOGY,158(1),77-87.
MLA Wu, Li-Yuan,et al."Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C".CLINICAL IMMUNOLOGY 158.1(2015):77-87.
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