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学科主题: 临床医学
题名:
Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C
作者: Wu, Li-Yuan1; Liu, Shuhong1; Liu, Yuan1; Guo, Chaonan1; Li, Hanwei2; Li, Wenshu3; Jin, Xueyuan4; Zhang, Keming5; Zhao, Ping4; Wei, Lai6; Zhao, Jingmin1
关键词: Interleukin-22 ; Hepatitis C virus ; Liver fibrosis ; Hepatic stellate cell
刊名: CLINICAL IMMUNOLOGY
发表日期: 2015-05-01
DOI: 10.1016/j.clim.2015.03.003
卷: 158, 期:1, 页:77-87
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: B-VIRUS INFECTION ; TH17 CELLS ; DISEASE PROGRESSION ; VIRAL-HEPATITIS ; IMMUNE-RESPONSE ; SEVERITY ; IL-22 ; STAT3 ; MICE ; INFLAMMATION
英文摘要:

Interleukin-22 (IL-22) is known to play a critical role in liver immunity. However, the role of IL-22 in HCV-associated liver fibrosis is poorly understood. In this study, patients with HCV infection disclosed significant increases in peripheral numbers of IL-22-producing cells as well as in IL-22 plasma levels. In the liver, the increased intrahepatic IL-22(+) cells were positively correlated with fibrotic staging scores and clinical progression from CHC to cirrhosis. Moreover, the majority of IL-22 cells were located in fibrotic areas in the liver of patients with cirrhosis and co-localized with alpha-smooth muscle actin (alpha-SMA) positive hepatic stellate cells (HSCs). In vitro, administration of IL-22 was accompanied with inhibited LX-2 cell apoptosis, promoted LX-2 cell proliferation, increased expression of alpha-SMA, and up-regulated collagen production by LX-2 cells. Collectively, our data provide evidence that IL-22 may contribute to the fibrogenesis of HCV-associated liver fibrosis by activating HSCs. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 20122X10002-003 ; 2010jxgs099
项目资助者: Chinese National S&amp ; T Major Project for Infectious Diseases Control ; Clinical High-tech Key Project
WOS记录号: WOS:000354592600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64717
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing 302 Hosp, Ctr Clin Trial, Beijing 100039, Peoples R China
2.Beijing 302 Hosp, Dept Pathol & Hepatol, Beijing 100039, Peoples R China
3.Beijing 302 Hosp, Liver Cirrhosis Diag & Treatment Ctr, Beijing 100039, Peoples R China
4.Beijing 302 Hosp, Int Ctr Liver Dis Diag & Treatment, Beijing 100039, Peoples R China
5.Beijing 302 Hosp, Dept Hepatobiliary Surg, Beijing 100039, Peoples R China
6.Peking Univ, Peoples Hosp, Liver Dis Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Wu, Li-Yuan,Liu, Shuhong,Liu, Yuan,et al. Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C[J]. CLINICAL IMMUNOLOGY,2015,158(1):77-87.
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