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学科主题基础医学
Genome-Wide Analysis of Human MicroRNA Stability
Li, Yang1; Li, Zhixin2; Zhou, Shixin1; Wen, Jinhua1; Geng, Bin3,4; Yang, Jichun3,4; Cui, Qinghua4,5
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/368975
0
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
资助者New Century Excellent Talents in University ; National Natural Science Foundation of China ; New Century Excellent Talents in University ; National Natural Science Foundation of China
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]EMBRYONIC STEM-CELLS ; MESSENGER-RNA DECAY ; MAMMALIAN-CELLS ; GENE-EXPRESSION ; DATABASE ; TURNOVER ; DEGRADATION ; REVEALS ; ARABIDOPSIS ; TRANSCRIPTS
英文摘要

Increasing studies have shown that microRNA (miRNA) stability plays important roles in physiology. However, the global picture of miRNA stability remains largely unknown. Here, we had analyzed genome-wide miRNA stability across 10 diverse cell types using miRNA arrays. We found that miRNA stability shows high dynamics and diversity both within individual cells and across cell types. Strikingly, we observed a negative correlation between miRNA stability and miRNA expression level, which is different from current findings on other biological molecules such as proteins and mRNAs that show positive and not negative correlations between stability and expression level. This finding indicates that miRNA has a distinct action mode, which we called "rapid production, rapid turnover; slow production, slow turnover." This mode further suggests that high expression miRNAs normally degrade fast and may endow the cell with special properties that facilitate cellular status-transition. Moreover, we revealed that the stability of miRNAs is affected by cohorts of factors that include miRNA targets, transcription factors, nucleotide content, evolution, associated disease, and environmental factors. Together, our results provided an extensive description of the global landscape, dynamics, and distinct mode of human miRNA stability, which provide help in investigating their functions in physiology and pathophysiology.

语种英语
所属项目编号31000653
资助者New Century Excellent Talents in University ; National Natural Science Foundation of China ; New Century Excellent Talents in University ; National Natural Science Foundation of China
WOS记录号WOS:000325408000001
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64719
专题基础医学院_北京大学干细胞研究中心
作者单位1.Peking Univ, Sch Basic Med Sci, Stem Cell Res Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrated Chinese & Western Med, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
4.Peking Univ, MOE Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Biomed Informat, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Yang,Li, Zhixin,Zhou, Shixin,et al. Genome-Wide Analysis of Human MicroRNA Stability[J]. BIOMED RESEARCH INTERNATIONAL,2013(0).
APA Li, Yang.,Li, Zhixin.,Zhou, Shixin.,Wen, Jinhua.,Geng, Bin.,...&Cui, Qinghua.(2013).Genome-Wide Analysis of Human MicroRNA Stability.BIOMED RESEARCH INTERNATIONAL(0).
MLA Li, Yang,et al."Genome-Wide Analysis of Human MicroRNA Stability".BIOMED RESEARCH INTERNATIONAL .0(2013).
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