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学科主题基础医学
Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells
Xie, Hong1; Hu, Jia1,2; Pan, Huan2; Lou, Yaxin2,3; Lv, Ping1,2; Chen, Yingyu1,2
关键词Anti-tumor activity Apoptosis Autophagy Cell cycle FAM176A
刊名BMB REPORTS
2014-02-28
DOI10.5483/BMBRep.2014.47.2.090
47期:2页:104-109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]TRANSMEMBRANE PROTEIN ; EXPRESSION ; P53 ; APOPTOSIS ; AUTOPHAGY ; TMEM166 ; CARCINOMA ; CHINA
英文摘要

FAM176A (family with sequence similarity 176 member A) is a novel molecule related to programmed cell death. A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers. In the present study, we investigated the biological activities of FAM176A on the human non-small cell lung cancer cell line H1299 cells. We constructed a recombinant adenovirus 5-FAM176A vector (Ad5-FAM176A) and evaluated the expression and anti-tumor activities in vitro. Cell viability analysis revealed that the adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells in a dose-and time-dependent manner. This inhibitory effect was mediated by both autophagy and apoptosis that involved caspase activation. In addition, cell cycle analysis suggested that Ad5-FAM176A could induce cell cycle arrest at the G2/M phase, all of which suggested that adenovirus-mediated FAM176A gene transfer might present a new therapeutic approach for lung cancer treatment.

语种英语
WOS记录号WOS:000332148200008
项目编号2011CB910103 ; 30771057 ; J1030831/J0108
资助机构National Key Project for Basic Research of China (973) ; National Natural Science Foundation of China ; National Science Foundation for Fostering Talents in Basic Research of the National
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64727
专题北京大学基础医学院_免疫学系
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genom, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Med & Hlth Analyt Ctr, Prote Lab, Beijing 100191, Peoples R China
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GB/T 7714
Xie, Hong,Hu, Jia,Pan, Huan,et al. Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells[J]. BMB REPORTS,2014,47(2):104-109.
APA Xie, Hong,Hu, Jia,Pan, Huan,Lou, Yaxin,Lv, Ping,&Chen, Yingyu.(2014).Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells.BMB REPORTS,47(2),104-109.
MLA Xie, Hong,et al."Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells".BMB REPORTS 47.2(2014):104-109.
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