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Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China
Zhou, Xianghai3,4,5; Pang, Zengchang1; Gao, Weiguo2,3; Wang, Shaojie1; Zhang, Lei2,3; Ning, Feng3; Qiao, Qing2,3
刊名DIABETES CARE
2010-03-01
DOI10.2337/dc09-1410
33期:3页:545-550
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]PLASMA-GLUCOSE ; CARDIOVASCULAR-DISEASE ; US POPULATION ; FOLLOW-UP ; HEMOGLOBIN ; RISK ; MORTALITY ; FRUCTOSAMINE ; ASSOCIATION ; PREVALENCE
英文摘要

OBJECTIVE - The study′s goal was to evaluate the performance of A] C and lasting capillary blood glucose (FCG) tests as mass screening tools for diabetes and pre-diabetes, as determined by the standard oral glucose tolerance test (OGTT).

RESEARCH DESIGN AND METHODS - Data from 2,332 individuals aged 35-74 years who participated in a population-based cross-sectional diabetes survey in Qingdao, China, were analyzed. A 2-h 75-g OGTT was used to diagnose diabetes. The performance of A1C and FCG was evaluated against the results of the OGTTs by using receiver operating characteristic curve (ROC) analysis.

RESULTS - The prevalence of newly diagnosed diabetes and pre-diabetes (impaired fasting glucose and/or impaired glucose tolerance) was 11.9 and 29.5%, respectively. For subjects with newly diagnosed diabetes, the area under the ROC curve was 0.67 for A1C and 0.77 for FCG (P < 0.01) in men and 0.67 and 0.75 (P < 0.01) in women, whereas for pre-diabetes, these values were 0.47 and 0.64 (P < 0.001) in men and 0.51 and 0.65 (P < 0.001.) in women. At the optimal A1C cutoff point of >= 5.6% for newly diagnosed diabetes, sensitivities (specificities) were 64.4% (61.6%) for men and 62.3% (63.3%) for women.

CONCLUSIONS - As a screening tool for newly diagnosed diabetes and pre-diabetes, the FCG measurement performed better than A I C in this general Chinese population.

语种英语
WOS记录号WOS:000275562700018
项目编号118492
资助机构Finnish Academy ; Bayer HealthCare Company, Shanghai, China
引用统计
被引频次:76[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64730
专题北京大学第二临床医学院
作者单位1.Qingdao Ctr Dis Control & Prevent, Qingdao, Peoples R China
2.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
3.Peking Univ, Ctr Diabet, Beijing 100871, Peoples R China
4.Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
5.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Xianghai,Pang, Zengchang,Gao, Weiguo,et al. Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China[J]. DIABETES CARE,2010,33(3):545-550.
APA Zhou, Xianghai.,Pang, Zengchang.,Gao, Weiguo.,Wang, Shaojie.,Zhang, Lei.,...&Qiao, Qing.(2010).Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China.DIABETES CARE,33(3),545-550.
MLA Zhou, Xianghai,et al."Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China".DIABETES CARE 33.3(2010):545-550.
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