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学科主题: 临床医学
题名:
Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China
作者: Zhou, Xianghai3,4,5; Pang, Zengchang1; Gao, Weiguo2,3; Wang, Shaojie1; Zhang, Lei2,3; Ning, Feng3; Qiao, Qing2,3
刊名: DIABETES CARE
发表日期: 2010-03-01
DOI: 10.2337/dc09-1410
卷: 33, 期:3, 页:545-550
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: PLASMA-GLUCOSE ; CARDIOVASCULAR-DISEASE ; US POPULATION ; FOLLOW-UP ; HEMOGLOBIN ; RISK ; MORTALITY ; FRUCTOSAMINE ; ASSOCIATION ; PREVALENCE
英文摘要:

OBJECTIVE - The study′s goal was to evaluate the performance of A] C and lasting capillary blood glucose (FCG) tests as mass screening tools for diabetes and pre-diabetes, as determined by the standard oral glucose tolerance test (OGTT).

RESEARCH DESIGN AND METHODS - Data from 2,332 individuals aged 35-74 years who participated in a population-based cross-sectional diabetes survey in Qingdao, China, were analyzed. A 2-h 75-g OGTT was used to diagnose diabetes. The performance of A1C and FCG was evaluated against the results of the OGTTs by using receiver operating characteristic curve (ROC) analysis.

RESULTS - The prevalence of newly diagnosed diabetes and pre-diabetes (impaired fasting glucose and/or impaired glucose tolerance) was 11.9 and 29.5%, respectively. For subjects with newly diagnosed diabetes, the area under the ROC curve was 0.67 for A1C and 0.77 for FCG (P < 0.01) in men and 0.67 and 0.75 (P < 0.01) in women, whereas for pre-diabetes, these values were 0.47 and 0.64 (P < 0.001) in men and 0.51 and 0.65 (P < 0.001.) in women. At the optimal A1C cutoff point of >= 5.6% for newly diagnosed diabetes, sensitivities (specificities) were 64.4% (61.6%) for men and 62.3% (63.3%) for women.

CONCLUSIONS - As a screening tool for newly diagnosed diabetes and pre-diabetes, the FCG measurement performed better than A I C in this general Chinese population.

语种: 英语
所属项目编号: 118492
项目资助者: Finnish Academy ; Bayer HealthCare Company, Shanghai, China
WOS记录号: WOS:000275562700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64730
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Qingdao Ctr Dis Control & Prevent, Qingdao, Peoples R China
2.Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
3.Peking Univ, Ctr Diabet, Beijing 100871, Peoples R China
4.Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
5.Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Xianghai,Pang, Zengchang,Gao, Weiguo,et al. Performance of an A1C and Fasting Capillary Blood Glucose Test for Screening Newly Diagnosed Diabetes and Pre-Diabetes Defined by an Oral Glucose Tolerance Test in Qingdao, China[J]. DIABETES CARE,2010,33(3):545-550.
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