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学科主题: 临床医学
题名:
Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer
作者: Li, Zi-Yu; Shan, Fei; Zhang, Lian-Hai; Bu, Zhao-De; Wu, Ai-Wen; Wu, Xiao-Jiang; Zong, Xiang-Long; Wu, Qi; Ren, Hui; Ji, Jia-Fu
关键词: Gastric cancer ; neoadjuvant chemotherapy ; complication ; FOLFOX7 ; surgery
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2011-09-26
DOI: 10.1186/1477-7819-9-110
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: PHASE-II ; POSTOPERATIVE COMPLICATIONS ; PREOPERATIVE CHEMOTHERAPY ; CARCINOMA ; MORBIDITY ; MORTALITY ; TRIAL ; CISPLATIN ; THERAPY ; STOMACH
英文摘要:

Background: This study assessed the postoperative morbidity and mortality occurring in the first 30 days after radical gastrectomy by comparing gastric cancer patients who did or did not receive the FOLFOX7 regimen of neoadjuvant chemotherapy.

Methods: We completed a retrospective analysis of 377 patients after their radical gastrectomies were performed in our department between 2005 and 2009. Two groups of patients were studied: the SURG group received surgical treatment immediately after diagnosis; the NACT underwent surgery after 2-6 cycles of neoadjuvant chemotherapy.

Results: There were 267 patients in the SURG group and 110 patients in the NACT group. The NACT group had more proximal tumours (P = 0.000), more total/proximal gastrectomies (P = 0.000) and longer operative time (P = 0.005) than the SURG group. Morbidity was 10.0% in the NACT patients and 17.2% in the SURG patients (P = 0.075). There were two cases of postoperative death, both in the SURG group (P = 1.000). No changes in complications or mortality rate were observed between the SURG and NACT groups.

Conclusion: The FOLFOX7 neoadjuvant chemotherapy is not associated with increased postoperative morbidity, indicating that the FOLFOX7 neoadjuvant chemotherapy is a safe choice for the treatment of local advanced gastric cancer.

语种: 英语
WOS记录号: WOS:000296743800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64731
Appears in Collections:北京大学临床肿瘤学院_肿瘤外科_期刊论文

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作者单位: Peking Univ, Dept Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Li, Zi-Yu,Shan, Fei,Zhang, Lian-Hai,et al. Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9.
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