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学科主题临床医学
Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer
Li, Zi-Yu; Shan, Fei; Zhang, Lian-Hai; Bu, Zhao-De; Wu, Ai-Wen; Wu, Xiao-Jiang; Zong, Xiang-Long; Wu, Qi; Ren, Hui; Ji, Jia-Fu
关键词Gastric cancer neoadjuvant chemotherapy complication FOLFOX7 surgery
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2011-09-26
DOI10.1186/1477-7819-9-110
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]PHASE-II ; POSTOPERATIVE COMPLICATIONS ; PREOPERATIVE CHEMOTHERAPY ; CARCINOMA ; MORBIDITY ; MORTALITY ; TRIAL ; CISPLATIN ; THERAPY ; STOMACH
英文摘要

Background: This study assessed the postoperative morbidity and mortality occurring in the first 30 days after radical gastrectomy by comparing gastric cancer patients who did or did not receive the FOLFOX7 regimen of neoadjuvant chemotherapy.

Methods: We completed a retrospective analysis of 377 patients after their radical gastrectomies were performed in our department between 2005 and 2009. Two groups of patients were studied: the SURG group received surgical treatment immediately after diagnosis; the NACT underwent surgery after 2-6 cycles of neoadjuvant chemotherapy.

Results: There were 267 patients in the SURG group and 110 patients in the NACT group. The NACT group had more proximal tumours (P = 0.000), more total/proximal gastrectomies (P = 0.000) and longer operative time (P = 0.005) than the SURG group. Morbidity was 10.0% in the NACT patients and 17.2% in the SURG patients (P = 0.075). There were two cases of postoperative death, both in the SURG group (P = 1.000). No changes in complications or mortality rate were observed between the SURG and NACT groups.

Conclusion: The FOLFOX7 neoadjuvant chemotherapy is not associated with increased postoperative morbidity, indicating that the FOLFOX7 neoadjuvant chemotherapy is a safe choice for the treatment of local advanced gastric cancer.

语种英语
WOS记录号WOS:000296743800001
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64731
Collection北京大学临床肿瘤学院_肿瘤外科
作者单位Peking Univ, Dept Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Li, Zi-Yu,Shan, Fei,Zhang, Lian-Hai,et al. Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9.
APA Li, Zi-Yu.,Shan, Fei.,Zhang, Lian-Hai.,Bu, Zhao-De.,Wu, Ai-Wen.,...&Ji, Jia-Fu.(2011).Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer.WORLD JOURNAL OF SURGICAL ONCOLOGY,9.
MLA Li, Zi-Yu,et al."Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer".WORLD JOURNAL OF SURGICAL ONCOLOGY 9(2011).
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