|Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer|
|Li, Zi-Yu; Shan, Fei; Zhang, Lian-Hai; Bu, Zhao-De; Wu, Ai-Wen; Wu, Xiao-Jiang; Zong, Xiang-Long; Wu, Qi; Ren, Hui; Ji, Jia-Fu|
|关键词||Gastric cancer neoadjuvant chemotherapy complication FOLFOX7 surgery|
|刊名||WORLD JOURNAL OF SURGICAL ONCOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Oncology ; Surgery|
|研究领域[WOS]||Oncology ; Surgery|
|关键词[WOS]||PHASE-II ; POSTOPERATIVE COMPLICATIONS ; PREOPERATIVE CHEMOTHERAPY ; CARCINOMA ; MORBIDITY ; MORTALITY ; TRIAL ; CISPLATIN ; THERAPY ; STOMACH|
Background: This study assessed the postoperative morbidity and mortality occurring in the first 30 days after radical gastrectomy by comparing gastric cancer patients who did or did not receive the FOLFOX7 regimen of neoadjuvant chemotherapy.
Methods: We completed a retrospective analysis of 377 patients after their radical gastrectomies were performed in our department between 2005 and 2009. Two groups of patients were studied: the SURG group received surgical treatment immediately after diagnosis; the NACT underwent surgery after 2-6 cycles of neoadjuvant chemotherapy.
Results: There were 267 patients in the SURG group and 110 patients in the NACT group. The NACT group had more proximal tumours (P = 0.000), more total/proximal gastrectomies (P = 0.000) and longer operative time (P = 0.005) than the SURG group. Morbidity was 10.0% in the NACT patients and 17.2% in the SURG patients (P = 0.075). There were two cases of postoperative death, both in the SURG group (P = 1.000). No changes in complications or mortality rate were observed between the SURG and NACT groups.
Conclusion: The FOLFOX7 neoadjuvant chemotherapy is not associated with increased postoperative morbidity, indicating that the FOLFOX7 neoadjuvant chemotherapy is a safe choice for the treatment of local advanced gastric cancer.
|作者单位||Peking Univ, Dept Surg, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China|
|Li, Zi-Yu,Shan, Fei,Zhang, Lian-Hai,et al. Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9.|
|APA||Li, Zi-Yu.,Shan, Fei.,Zhang, Lian-Hai.,Bu, Zhao-De.,Wu, Ai-Wen.,...&Ji, Jia-Fu.(2011).Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer.WORLD JOURNAL OF SURGICAL ONCOLOGY,9.|
|MLA||Li, Zi-Yu,et al."Complications after radical gastrectomy following FOLFOX7 neoadjuvant chemotherapy for gastric cancer".WORLD JOURNAL OF SURGICAL ONCOLOGY 9(2011).|