IR@PKUHSC  > 北京大学口腔医学院  > 综合治疗科
学科主题口腔医学
Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells
Zhu, W.1; Zhu, X.2,3; Huang, G. T. -J.4,5; Cheung, G. S. P.3; Dissanayaka, W. L.3; Zhang, C.3
关键词dental pulp cells immature teeth platelet-rich plasma regenerative endodontics
刊名INTERNATIONAL ENDODONTIC JOURNAL
2013-10-01
DOI10.1111/iej.12087
46期:10页:962-970
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Grants Council of Hong Kong ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Grants Council of Hong Kong
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MESENCHYMAL STEM-CELLS ; BONE REGENERATION ; PERMANENT TOOTH ; IN-VITRO ; REVASCULARIZATION ; GROWTH ; GRAFTS ; REPAIR ; MOLARS
英文摘要

Aim To investigate the new tissues growing into the pulp space of immature dog teeth that were infected, disinfected and filled with blood clot (BC), dental pulp cells (DPCs), platelet-rich plasma (PRP) or a combination of DPCs and PRP in immature dog teeth with apical periodontitis.

Methodology Fifty-six immature roots from mandibular premolars of four beagles were divided into four experimental groups (n = 40) and two control groups. After the induction of apical periodontitis, the root canals of experimental groups were disinfected with NaOCl irrigation and a tri-antibiotic paste medication. The canals were then filled with different materials according to the experimental group: BC group, DPCs group, PRP group or DPCs + PRP group. Access cavities were sealed with MTA and composite. Radiographs were taken after 90 days, and the jaws including the teeth were processed for histologic analysis. The data were statistically analysed using chi-square evaluation and Student′s t-test.

Results Radiographic analyses demonstrated no significant difference between experimental groups in periradicular bone healing (P > 0.05), whilst those groups that used DPCs produced a significantly greater root thickening (P < 0.01). The histologic evaluation showed that the groups with PRP formed more tissues in the canals (P = 0.01). The groups with DPCs had substantially more mineralized tissue formation in the canal than those without DPCs, especially in the apical third. In DPCs + PRP group, bone-like tissue grew into the canal space from the periapical tissue.

Conclusions A combination of DPCs + PRP increased vital tissue regeneration within the root canals of immature teeth associated with apical periodontitis.

语种英语
所属项目编号2009DFA32950 ; HKU 785010M
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Grants Council of Hong Kong ; Ministry of Science and Technology of the People&prime ; s Republic of China ; Research Grants Council of Hong Kong
WOS记录号WOS:000323885300010
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64733
Collection北京大学口腔医学院_综合治疗科
作者单位1.Boston Univ, Sch Dent Med, Dept Endodont, Boston, MA 02215 USA
2.Peking Univ, Sch & Hosp Stomatol, Dept Gen Dent, Beijing 100871, Peoples R China
3.Peking Univ, Special Dept Sch & Hosp Stomatol, Beijing 100871, Peoples R China
4.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China
5.Univ Tennessee, Ctr Hlth Sci, Coll Dent, Dept Biosci Res, Memphis, TN 38163 USA
Recommended Citation
GB/T 7714
Zhu, W.,Zhu, X.,Huang, G. T. -J.,et al. Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells[J]. INTERNATIONAL ENDODONTIC JOURNAL,2013,46(10):962-970.
APA Zhu, W.,Zhu, X.,Huang, G. T. -J.,Cheung, G. S. P.,Dissanayaka, W. L.,&Zhang, C..(2013).Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells.INTERNATIONAL ENDODONTIC JOURNAL,46(10),962-970.
MLA Zhu, W.,et al."Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells".INTERNATIONAL ENDODONTIC JOURNAL 46.10(2013):962-970.
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