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学科主题: 基础医学
题名:
A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells
作者: Zhang, Qiao1; Yang, Zhe1; Wang, Weiping1; Guo, Ting2; Jia, Zhuqing1; Ma, Kangtao1; Zhou, Chunyan1
关键词: 1SL-1 ; Pancreatic beta-cell ; DLBCL ; Feedback regulation
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-07-04
DOI: 10.1016/j.bbrc.2014.05.021
卷: 449, 期:3, 页:295-300
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: HOMEOBOX GENE ISL-1 ; SUBUNIT VB PROMOTER ; INITIATOR ELEMENT ; SIGNAL TRANSDUCER ; EXPRESSION ; TRANSCRIPTION ; PROTEIN ; DOMAIN ; IDENTIFICATION ; ACTIVATOR
英文摘要:

Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, has been reported to play essential roles in promoting adult pancreatic beta-cells proliferation. Recent studies indicate that ISL-1 may also involve in the occurrence of a variety of tumors. However, whether ISL-1 has any functional effect on tumorigenesis, and what are the differences on ISL-1 function in distinct conditions, are completely unknown. In this study, we found that ISL-1 was highly expressed in human pancreatic beta-cells, as well as in diffuse large B cell lymphoma (DLBCL), but to a much less extent in other normal tissues or tumor specimens. Further study revealed that ISL-1 promoted the proliferation of pancreatic beta-cells and DLBCL cells, and also accelerated the tumorigenesis of DLBCL in vivo. We also found that ISL-1 could activate c-Myc transcription not only in pancreatic beta-cells but also in DLBCL cells. However, a cell-specific feedback regulation was detectable only in DLBCL cells. This auto-regulatory loop was established by the interaction of ISL-1 and c-Myc to form an ISL-1/c-Myc transcriptional complex, and synergistically to promote ISL-1 transcription through binding on the ISL-1 promoter. Taken together, our results demonstrate a positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells, which might result in the functional diversities of ISL-1 in different physiological and pathological processes. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 81071675 ; 81170713 ; 81370236 ; 5122021 ; B07001
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Leading Academic Discipline Project of Beijing Education Bureau ; 111 Project of China
WOS记录号: WOS:000337781500007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64734
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Dept Biochem & Mol Biol,Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp, Minist Educ, Dept Gastrointestinal Translat Res,Key Lab Carcin, Beijing 100142, Peoples R China

Recommended Citation:
Zhang, Qiao,Yang, Zhe,Wang, Weiping,et al. A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,449(3):295-300.
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