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学科主题基础医学
A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells
Zhang, Qiao1; Yang, Zhe1; Wang, Weiping1; Guo, Ting2; Jia, Zhuqing1; Ma, Kangtao1; Zhou, Chunyan1
关键词1SL-1 Pancreatic beta-cell DLBCL Feedback regulation
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-07-04
DOI10.1016/j.bbrc.2014.05.021
449期:3页:295-300
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]HOMEOBOX GENE ISL-1 ; SUBUNIT VB PROMOTER ; INITIATOR ELEMENT ; SIGNAL TRANSDUCER ; EXPRESSION ; TRANSCRIPTION ; PROTEIN ; DOMAIN ; IDENTIFICATION ; ACTIVATOR
英文摘要

Insulin enhancer binding protein-1 (ISL-1), a LIM-homeodomain transcription factor, has been reported to play essential roles in promoting adult pancreatic beta-cells proliferation. Recent studies indicate that ISL-1 may also involve in the occurrence of a variety of tumors. However, whether ISL-1 has any functional effect on tumorigenesis, and what are the differences on ISL-1 function in distinct conditions, are completely unknown. In this study, we found that ISL-1 was highly expressed in human pancreatic beta-cells, as well as in diffuse large B cell lymphoma (DLBCL), but to a much less extent in other normal tissues or tumor specimens. Further study revealed that ISL-1 promoted the proliferation of pancreatic beta-cells and DLBCL cells, and also accelerated the tumorigenesis of DLBCL in vivo. We also found that ISL-1 could activate c-Myc transcription not only in pancreatic beta-cells but also in DLBCL cells. However, a cell-specific feedback regulation was detectable only in DLBCL cells. This auto-regulatory loop was established by the interaction of ISL-1 and c-Myc to form an ISL-1/c-Myc transcriptional complex, and synergistically to promote ISL-1 transcription through binding on the ISL-1 promoter. Taken together, our results demonstrate a positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells, which might result in the functional diversities of ISL-1 in different physiological and pathological processes. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000337781500007
项目编号81071675 ; 81170713 ; 81370236 ; 5122021 ; B07001
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Leading Academic Discipline Project of Beijing Education Bureau ; 111 Project of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64734
专题北京大学基础医学院_心血管所
北京大学基础医学院
北京大学临床肿瘤学院_603课题组
作者单位1.Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Dept Biochem & Mol Biol,Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Canc Hosp, Minist Educ, Dept Gastrointestinal Translat Res,Key Lab Carcin, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Qiao,Yang, Zhe,Wang, Weiping,et al. A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,449(3):295-300.
APA Zhang, Qiao.,Yang, Zhe.,Wang, Weiping.,Guo, Ting.,Jia, Zhuqing.,...&Zhou, Chunyan.(2014).A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,449(3),295-300.
MLA Zhang, Qiao,et al."A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic beta-cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 449.3(2014):295-300.
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