|Educational Level, Obesity and Incidence of Diabetes among Chinese Adult Men and Women Aged 18-59 Years Old: An 11-Year Follow-Up Study|
|Shang, Xianwen1,2; Li, Jiongyi3; Tao, Qiushan4; Li, Jing1,2; Li, Xi1,2; Zhang, Lihua1,2; Liu, Xiancheng3; Wang, Qing1,2; Shi, Xiuzhong3; Zhao, Yuhong3; Hu, Shuang1,2; Jiang, Lixin1,2; Yang, Ying3|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||RISK-FACTORS ; LIFE-STYLE ; SOCIOECONOMIC-STATUS ; METABOLIC SYNDROME ; PHYSICAL-ACTIVITY ; WHITEHALL II ; TYPE-2 ; PREVALENCE ; PREVENTION ; AMERICAN|
Objective: To determine whether educational level and overweight/obesity was associated with the development of diabetes among Chinese adult men and women.
Methods: A cohort (2000-2011) of 10 704 participants aged 18-59 years (8 238 men, 2 466 women) in Qingdao Port Health Study (QPHS) were recruited in this study. The personal lifestyle, height, weight, waist circumference, resting heart rate, blood pressure, fasting blood glucose, total cholesterol, triglycerides and plasma uric acid were collected annually in a comprehensive health checkup program. Cox proportional hazards regression models were used to estimate the association of factors and incidence of diabetes.
Results: During 110 825 person-years of follow-up, 1 056 new onset cases (9.5 per 1 000 person-years) of diabetes were identified. With normal weight as reference, the multiple-adjusted hazard ratio (HR) (95% CI) of diabetes was 1.69(1.38-2.09) for overweight and 2.24(1.66-3.02) for obesity among men, which was 1.81(1.12-2.92) and 2.58(1.37-4.86) among women, respectively. Compared with the participants with high educational level, those with low educational level had a higher risk of diabetes (multiple-adjusted HR (95% CI): 1.43(1.11-1.86)) among men. The association was not found among women and the adjusted HR (95% CI) of diabetes was 1.56(0.89-2.76). The increased risks of low educational level were independent of mediators among men, through normal weight (P for trend = 0.0313) and overweight (P for trend = 0.0212) group but not obesity group (P for trend = 0.0957).
Conclusion: Baseline overweight/obesity was an independent risk factor for diabetes for both men and women. Low educational level was adversely associated with incidence of diabetes through normal weight, overweight and obesity groups, with the association being substantially attenuated by mediating factors only in the obesity group among men. The association was not found among women.
|作者单位||1.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, China Oxford Ctr Int Hlth Res,State Key Lab Cardi, Beijing 100730, Peoples R China|
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Qingdao Fuwai Hosp, Qingdao, Shandong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
|Shang, Xianwen,Li, Jiongyi,Tao, Qiushan,et al. Educational Level, Obesity and Incidence of Diabetes among Chinese Adult Men and Women Aged 18-59 Years Old: An 11-Year Follow-Up Study[J]. PLOS ONE,2013,8(6).|
|APA||Shang, Xianwen.,Li, Jiongyi.,Tao, Qiushan.,Li, Jing.,Li, Xi.,...&Yang, Ying.(2013).Educational Level, Obesity and Incidence of Diabetes among Chinese Adult Men and Women Aged 18-59 Years Old: An 11-Year Follow-Up Study.PLOS ONE,8(6).|
|MLA||Shang, Xianwen,et al."Educational Level, Obesity and Incidence of Diabetes among Chinese Adult Men and Women Aged 18-59 Years Old: An 11-Year Follow-Up Study".PLOS ONE 8.6(2013).|