北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Peroxisome proliferator-activated receptor-alpha is renoprotective in doxorubicin-induced glomerular injury
作者: Zhou, Yunfeng1; Kong, Xiaomu1; Zhao, Pan1; Yang, Hang1; Chen, Lihong1; Miao, Jing2; Zhang, Xiaoyan1; Yang, Jichun1; Ding, Jie2; Guan, Youfei1,3,4
关键词: doxorubicin ; fenofibrate ; peroxisome proliferator-activated receptor ; podocyte injury ; proteinuria
刊名: KIDNEY INTERNATIONAL
发表日期: 2011-06-01
DOI: 10.1038/ki.2011.17
卷: 79, 期:12, 页:1302-1311
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: ACUTE-RENAL-FAILURE ; NEPHROTIC SYNDROME ; PODOCYTE INJURY ; DIABETIC-NEPHROPATHY ; METABOLIC SYNDROME ; LIPID-METABOLISM ; TUBULAR CELLS ; EXPRESSION ; PROTECTS ; MICE
英文摘要:

Doxorubicin (DOX) is an anthracycline antibiotic utilized in antitumor therapy; however, its clinical use is frequently impeded by renal toxic effects. As peroxisome proliferator-activated receptor-alpha (PPAR-alpha) has renoprotective effects in drug-related kidney injuries, we tested its ability to inhibit DOX-induced renal injury. Although both male PPAR-alpha knockout mice and their wild-type littermates (pure 129/SvJ background) had significant proteinuria 4 weeks after DOX treatment, those with deletion of PPAR-alpha had more severe proteinuria. This was associated with more serious podocyte foot process effacement compared with wild-type mice. In contrast, the PPAR-alpha agonist fenofibrate effectively reduced proteinuria and attenuated DOX-induced podocyte foot process effacement. Consistently, glomerular nephrin expression was significantly lower in the knockout compared with wild-type mice following DOX treatment. Fenofibrate therapy significantly blunted the reduction in glomerular nephrin levels in DOX-treated wild-type mice. In cultured podocytes, DOX induced apoptosis, increased cleaved caspase-3 levels, and decreased Bcl-2 expression, all attenuated by pretreatment with fenofibrate. Thus, PPAR-alpha deficiency exacerbates DOX-related renal injury, in part, due to increased podocyte apoptosis. Kidney International (2011) 79, 1302-1311; doi:10.1038/ki.2011.17; published online 2 March 2011

语种: 英语
所属项目编号: 30890041 ; 81030003 ; 30870905 ; 30725033 ; 2010CB912503 ; NIDDK RO1 065074-04 ; PPG 038226
项目资助者: National Natural Science Foundation of China (NSFC) ; Ministry of Science and Technology ; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
WOS记录号: WOS:000291093300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64746
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 1000191, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 1000191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Ctr Diabet, Beijing 1000191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Cardiovasc Sci, Beijing 1000191, Peoples R China

Recommended Citation:
Zhou, Yunfeng,Kong, Xiaomu,Zhao, Pan,et al. Peroxisome proliferator-activated receptor-alpha is renoprotective in doxorubicin-induced glomerular injury[J]. KIDNEY INTERNATIONAL,2011,79(12):1302-1311.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Yunfeng]'s Articles
[Kong, Xiaomu]'s Articles
[Zhao, Pan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Yunfeng]‘s Articles
[Kong, Xiaomu]‘s Articles
[Zhao, Pan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace