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What is the Role of Unripe Rubus coreanus Extract on Penile Erection?
Zhao, Chen1; Kim, Hye Kyung1; Kim, Sung Zoo2; Chae, Han Jung3; Cui, Wan Shou4; Lee, Sung Won5; Jeon, Ju Hong6; Park, Jong Kwan1,7,8,9
关键词Rubus coreanus penile corpus cavernosum (PCC) penile perfusion model sildenafil NO-cGMP system
刊名PHYTOTHERAPY RESEARCH
2011-07-01
DOI10.1002/ptr.3393
25期:7页:1046-1053
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]RADICAL SCAVENGING ACTIVITY ; NITRIC-OXIDE ; CORPUS CAVERNOSUM ; ANTIOXIDANT ; DYSFUNCTION ; CGMP ; EXPRESSION ; MODEL
英文摘要

The effect of unripe Rubus coreanus extract on rabbit penile corpus cavernosum (PCC) was evaluated. Penises were obtained from healthy male New Zealand white rabbits (2.5-3.0 kg). The pre-contracted penis with phenylephrine (Phe, 10 mu M) was treated with various concentrations of an extract of unripe R. coreanus (0.5, 1, 2, 3 and 4 mg/mL). The change in penile tension was recorded, cyclic nucleotides in the perfusate and the PCC were measured by radioimmunoassay, and the expression of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) in the perfused PCC were measured by western blotting. The interaction between unripe R. coreanus and sildenafil was also evaluated. The PCC relaxation induced by the extracts of R. coreanus was in a concentration-dependent manner and enhanced sildenafil-induced PCC relaxation. The perfusion of penile cavernous tissue with the unripe R. coreanus extract increased cGMP and cAMP in the tissue and in the perfusate and the expression of eNOS and nNOS in the tissue. The unripe R. coreanus extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP system and it may improve erectile dysfunction (ED), which does not completely respond to sildenafil citrate. Copyright (C) 2011 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000293031400013
项目编号A90583
资助机构Ministry for Health, Welfare and Family Affairs, Republic of Korea
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64754
专题北京大学第一临床医学院_泌尿外科
北京大学临床肿瘤学院_重症监护病区
作者单位1.Peking Univ, Dept Urol, Beijing 100034, Peoples R China
2.Chonbuk Natl Univ Hosp, Dept Urol, Jeonju 561712, Jeonbuk, South Korea
3.Chonbuk Natl Univ Hosp, Dept Physiol, Jeonju 561712, Jeonbuk, South Korea
4.Chonbuk Natl Univ Hosp, Sch Med, Dept Pharmacol, Jeonju 561712, Jeonbuk, South Korea
5.Sungkyunkwan Univ, Sch Med, Dept Urol, Seoul 135710, South Korea
6.Seoul Natl Univ, Sch Med, Dept Physiol, Seoul 110799, South Korea
7.Chonbuk Natl Univ Hosp, Inst Med Sci, Jeonju 561712, Jeonbuk, South Korea
8.Chonbuk Natl Univ Hosp, CTC Med Device, Jeonju 561712, Jeonbuk, South Korea
9.Chonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju 561712, Jeonbuk, South Korea
推荐引用方式
GB/T 7714
Zhao, Chen,Kim, Hye Kyung,Kim, Sung Zoo,et al. What is the Role of Unripe Rubus coreanus Extract on Penile Erection?[J]. PHYTOTHERAPY RESEARCH,2011,25(7):1046-1053.
APA Zhao, Chen.,Kim, Hye Kyung.,Kim, Sung Zoo.,Chae, Han Jung.,Cui, Wan Shou.,...&Park, Jong Kwan.(2011).What is the Role of Unripe Rubus coreanus Extract on Penile Erection?.PHYTOTHERAPY RESEARCH,25(7),1046-1053.
MLA Zhao, Chen,et al."What is the Role of Unripe Rubus coreanus Extract on Penile Erection?".PHYTOTHERAPY RESEARCH 25.7(2011):1046-1053.
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