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学科主题: 药学
题名:
Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds
作者: Zeng, H. H.; Wang, L. H.
关键词: Thioredoxin reductase ; redox system ; antitumour agents ; TrxR substrates ; alkylating agents ; reversible TrxR inhibitor ; motexafin gadolinium ; ethaselen
刊名: MEDICINAL CHEMISTRY
发表日期: 2010-09-01
卷: 6, 期:5, 页:286-297
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: NF-KAPPA-B ; CANCER-CELL-LINES ; MOTEXAFIN GADOLINIUM ; IN-VITRO ; RIBONUCLEOTIDE REDUCTASE ; GLUTATHIONE-REDUCTASE ; MOLECULAR TARGETS ; ESCHERICHIA-COLI ; OXIDATIVE STRESS ; ACTIVE-SITE
英文摘要:

Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductase′s C-terminal redox center.

语种: 英语
项目资助者: State Key Laboratory of Natural and Biomimetic Drugs, Peking University ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; National Natural Science Foundation
WOS记录号: WOS:000284823000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64763
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zeng, H. H.,Wang, L. H.. Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds[J]. MEDICINAL CHEMISTRY,2010,6(5):286-297.
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