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Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds
Zeng, H. H.; Wang, L. H.
关键词Thioredoxin reductase redox system antitumour agents TrxR substrates alkylating agents reversible TrxR inhibitor motexafin gadolinium ethaselen
刊名MEDICINAL CHEMISTRY
2010-09-01
6期:5页:286-297
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]NF-KAPPA-B ; CANCER-CELL-LINES ; MOTEXAFIN GADOLINIUM ; IN-VITRO ; RIBONUCLEOTIDE REDUCTASE ; GLUTATHIONE-REDUCTASE ; MOLECULAR TARGETS ; ESCHERICHIA-COLI ; OXIDATIVE STRESS ; ACTIVE-SITE
英文摘要

Thioredoxin reductase plays a critical role in the regulation of cancer cell apoptosis, making it an attractive target for the design of new anticancer drugs. Several classes of compounds have been considered as potential antitumor or chemopreventive agents; most of them apparently interact with thioredoxin reductase′s C-terminal redox center.

语种英语
WOS记录号WOS:000284823000004
资助机构State Key Laboratory of Natural and Biomimetic Drugs, Peking University ; Beijing Municipal Science &amp ; Technology Commission ; Beijing Natural Science Foundation ; National Natural Science Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64763
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Zeng, H. H.,Wang, L. H.. Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds[J]. MEDICINAL CHEMISTRY,2010,6(5):286-297.
APA Zeng, H. H.,&Wang, L. H..(2010).Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds.MEDICINAL CHEMISTRY,6(5),286-297.
MLA Zeng, H. H.,et al."Targeting Thioredoxin Reductase: Anticancer Agents and Chemopreventive Compounds".MEDICINAL CHEMISTRY 6.5(2010):286-297.
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