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学科主题: 临床医学
题名:
Optic Nerve Head Change in Non-Arteritic Anterior Ischemic Optic Neuropathy and Its Influence on Visual Outcome
作者: Jonas, Jost B.1; Hayreh, Sohan Singh2,3; Tao, Yong4; Papastathopoulos, Konstantinos I.1; Rensch, Florian1
刊名: PLOS ONE
发表日期: 2012-05-21
DOI: 10.1371/journal.pone.0037499
卷: 7, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: OPEN-ANGLE GLAUCOMA ; DISC MORPHOLOGY ; BEIJING EYE ; PARAPAPILLARY ATROPHY ; COHERENCE TOMOGRAPHY ; ADULT CHINESE ; FIBER LAYER ; PATHOGENESIS ; RATIO ; CUP
英文摘要:

Purpose: To evaluate changes in cup/disc (C/D) diameter ratios and parapapillary atrophy in patients with non-arteritic anterior ischemic optic neuropathy (NA-AION), using morphometric methods.

Methods: The clinical non-interventional study included 157 patients with unilateral or bilateral NA-AION. Optic disc photographs taken from both eyes at the end of follow-up were morphometrically examined.

Results: Follow-up was 86.3 +/- 70.3 months. Horizontal and vertical disc diameters (P = 0.30; P = 0.61, respectively), horizontal and vertical C/D ratios (P = 0.47; P = 0.19, resp.), and size of alpha zone and beta zone of parapapillary atrophy (P = 0.27; P = 0.32, resp.) did not differ significantly between affected eyes and contralateral normal eyes in patients with unilateral NA-AION. Similarly, horizontal and vertical disc diameters, horizontal and vertical C/D ratios, and size of alpha zone and beta zone did not vary significantly (all P>0.05) between the unaffected eyes of patients with unilateral NA-AION and the eyes of patients with bilateral NA-AION. Optic disc diameters, C/D ratios, size of alpha zone or beta zone of parapapillary atrophy were not significantly associated with final visual outcome in the eyes affected with NA-AION (all P>0.20) nor with the difference in final visual acuity between affected eyes and unaffected eyes in patients with unilateral NA-AION (all P>0.25).

Conclusions: NA-AION did not affect C/D ratios nor alpha zone and beta zone of parapapillary atrophy. Optic disc size was not related to the final visual acuity outcome in NA-AION.

语种: 英语
所属项目编号: EY-1576
项目资助者: U.S. National Institutes of Health ; Research to Prevent Blindness, Incorporated, New York, United States of America
WOS记录号: WOS:000305343100036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64767
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Univ Iowa, Coll Med, Dept Ophthalmol, Iowa City, IA 52242 USA
2.Univ Iowa, Coll Med, Dept Visual Sci, Iowa City, IA USA
3.Univ Heidelberg, Dept Ophthalmol, Med Fac Mannheim, D-6800 Mannheim, Germany
4.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Jonas, Jost B.,Hayreh, Sohan Singh,Tao, Yong,et al. Optic Nerve Head Change in Non-Arteritic Anterior Ischemic Optic Neuropathy and Its Influence on Visual Outcome[J]. PLOS ONE,2012,7(5).
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