北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats
作者: Bao, Lei; Cai, Xiaxia; Dai, Xiaoqian; Ding, Ye; Jiang, Yanfei; Li, Yujie; Zhang, Zhaofeng; Li, Yong
刊名: FOOD & FUNCTION
发表日期: 2014-08-01
DOI: 10.1039/c4fo00340c
卷: 5, 期:8, 页:1872-1880
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Food Science & Technology
研究领域[WOS]: Biochemistry & Molecular Biology ; Food Science & Technology
关键词[WOS]: FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; OXIDATIVE STRESS ; MITOCHONDRIAL DYSFUNCTION ; ENDOTHELIAL-CELLS ; INDUCED OBESITY ; NEPHROPATHY ; PGC-1-ALPHA ; BIOGENESIS ; SUPPLEMENTATION ; PROTEINURIA
英文摘要:

Podocytes are part of the glomerular filtration membrane in kidney and serve to prevent the filtration of protein from the blood. Several evidences suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of diabetic nephropathy and it is an early event in podocyte injury. Mitochondrial dysfunction promotes oxidative stress that can favor the development of podocyte injury. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha) was considered to be a major regulator of metabolic homeostasis and mitochondria function. Some studies indicated that polyphenols may improve mitochondria dysfunction, maintain the podocyte integrity and have therapeutic effects on glomerular diseases by promoting PGC-1 alpha expression. Our study investigated whether grape seed proanthocyanidin extracts (GSPE), a strong antioxidant, ameliorate podocyte injury by activating PGC-1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. After 16 weeks of GSPE treatment, GSPE slightly increased the body weight and decreased plasma glucose, food intake, water intake and urine volume in diabetic rats. Further, GSPE significantly decreased 24 h albumin levels and increased the expression of nephrin and podocalyxin. The antioxidant levels were improved and the cellular damage of kidney in diabetic rats was also relieved effectively after the treatment. Moreover, GSPE increased the mRNA expression of mitochondrial biogenesis factors and mitochondrial DNA content. Finally, GSPE activated the expression of PGC-1 alpha, silent mating type information regulation 2 homolog 1 (SIRT1) and AMP-activated protein kinase (AMPK). These results suggest that GSPE ameliorate podocyte injury in diabetic nephropathy by the activation of AMPK-SIRT1-PGC-1 alpha signalling, which appears to inhibit oxidative stress and mitochondrial dysfunction in the kidney.

语种: 英语
所属项目编号: 81102116 ; 81072293 ; 20110001120026
项目资助者: National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000340698400024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64774
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China

Recommended Citation:
Bao, Lei,Cai, Xiaxia,Dai, Xiaoqian,et al. Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats[J]. FOOD & FUNCTION,2014,5(8):1872-1880.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Bao, Lei]'s Articles
[Cai, Xiaxia]'s Articles
[Dai, Xiaoqian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Bao, Lei]‘s Articles
[Cai, Xiaxia]‘s Articles
[Dai, Xiaoqian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace