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Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats
Bao, Lei; Cai, Xiaxia; Dai, Xiaoqian; Ding, Ye; Jiang, Yanfei; Li, Yujie; Zhang, Zhaofeng; Li, Yong
刊名FOOD & FUNCTION
2014-08-01
DOI10.1039/c4fo00340c
5期:8页:1872-1880
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Food Science & Technology
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Biochemistry & Molecular Biology ; Food Science & Technology
关键词[WOS]FOCAL SEGMENTAL GLOMERULOSCLEROSIS ; OXIDATIVE STRESS ; MITOCHONDRIAL DYSFUNCTION ; ENDOTHELIAL-CELLS ; INDUCED OBESITY ; NEPHROPATHY ; PGC-1-ALPHA ; BIOGENESIS ; SUPPLEMENTATION ; PROTEINURIA
英文摘要

Podocytes are part of the glomerular filtration membrane in kidney and serve to prevent the filtration of protein from the blood. Several evidences suggest that mitochondrial dysfunction plays a critical role in the pathogenesis of diabetic nephropathy and it is an early event in podocyte injury. Mitochondrial dysfunction promotes oxidative stress that can favor the development of podocyte injury. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha) was considered to be a major regulator of metabolic homeostasis and mitochondria function. Some studies indicated that polyphenols may improve mitochondria dysfunction, maintain the podocyte integrity and have therapeutic effects on glomerular diseases by promoting PGC-1 alpha expression. Our study investigated whether grape seed proanthocyanidin extracts (GSPE), a strong antioxidant, ameliorate podocyte injury by activating PGC-1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats. After 16 weeks of GSPE treatment, GSPE slightly increased the body weight and decreased plasma glucose, food intake, water intake and urine volume in diabetic rats. Further, GSPE significantly decreased 24 h albumin levels and increased the expression of nephrin and podocalyxin. The antioxidant levels were improved and the cellular damage of kidney in diabetic rats was also relieved effectively after the treatment. Moreover, GSPE increased the mRNA expression of mitochondrial biogenesis factors and mitochondrial DNA content. Finally, GSPE activated the expression of PGC-1 alpha, silent mating type information regulation 2 homolog 1 (SIRT1) and AMP-activated protein kinase (AMPK). These results suggest that GSPE ameliorate podocyte injury in diabetic nephropathy by the activation of AMPK-SIRT1-PGC-1 alpha signalling, which appears to inhibit oxidative stress and mitochondrial dysfunction in the kidney.

语种英语
所属项目编号81102116 ; 81072293 ; 20110001120026
资助者National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000340698400024
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64774
专题北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Bao, Lei,Cai, Xiaxia,Dai, Xiaoqian,et al. Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats[J]. FOOD & FUNCTION,2014,5(8):1872-1880.
APA Bao, Lei.,Cai, Xiaxia.,Dai, Xiaoqian.,Ding, Ye.,Jiang, Yanfei.,...&Li, Yong.(2014).Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats.FOOD & FUNCTION,5(8),1872-1880.
MLA Bao, Lei,et al."Grape seed proanthocyanidin extracts ameliorate podocyte injury by activating peroxisome proliferator-activated receptor-gamma coactivator 1 alpha in low-dose streptozotocin-and high-carbohydrate/high-fat diet-induced diabetic rats".FOOD & FUNCTION 5.8(2014):1872-1880.
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