学科主题 | 临床医学 |
Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice | |
Wang, Yanfei1; Zhao, Xia1; Jin, Hongfang1; Wei, Hongling1; Li, Wei1; Bu, Dingfang3; Tang, Xiuying4; Ren, Yali4; Tang, Chaoshu2; Du, Junbao1,2 | |
关键词 | hydrogen sulfide intercellular adhesion molecule-1 atherosclerosis apolipoprotein E knockout mice human umbilical vein endothelial cells |
刊名 | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
![]() |
2009-02-01 | |
DOI | 10.1161/ATVBAHA.108.179333 |
卷 | 29期:2页:173-U71 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Hematology ; Peripheral Vascular Disease |
资助者 | National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program ; National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program |
研究领域[WOS] | Hematology ; Cardiovascular System & Cardiology |
关键词[WOS] | E-DEFICIENT MICE ; CELL-ADHESION MOLECULES ; SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; LIFE-STYLE ; EXPRESSION ; INFLAMMATION ; INHIBITION ; HYPERCHOLESTEROLEMIA ; OXYGENASE |
英文摘要 | Objective-We explored the effect of hydrogen sulfide (H(2)S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE(-/-)) mice and human umbilical vein endothelial cells (HUVECs). Methods and Results-ApoE(-/-) mice were treated with sodium hydrosulfide (NaHS) or DL-propargylglycine (PPG); HUVECs were pretreated with NaHS. Compared with control mice, apoE(-/-) mice showed decreased plasma H(2)S level and aortic H(2)S production but increased plasma ICAM-1 and aortic ICAM-1 protein and mRNA. Compared with apoE(-/-) mice, apoE(-/-) +NaHS mice showed increased plasma H(2)S level, but decreased size of atherosclerotic plaque and plasma and aortic ICAM-1 levels, whereas apoE(-/-) +PPG mice showed decreased plasma H(2)S level but enlarged plaque size and increased plasma and aortic ICAM-1 levels. NaHS suppressed ICAM-1 expression in tumor necrosis factor (TNF)-alpha-treated HUVECs. NaHS inhibited I kappa B degradation and NF-kappa B nuclear translocation in HUVECs treated with TNF-alpha. Conclusions-The vascular CSE/H(2)S pathway was disturbed in apoE(-/-) mice. H(2)S exerted an antiatherogenic effect and inhibited ICAM-1 expression in apoE(-/-) mice. H(2)S inhibited ICAM-1 expression in TNF-alpha-induced HUVECs via the NF-kappa B pathway. (Arterioscler Thromb Vasc Biol. 2009; 29: 173-179.) |
语种 | 英语 |
所属项目编号 | 30630031 ; 30571971 ; 30425010 ; 2006CB503807 |
资助者 | National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program ; National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program |
WOS记录号 | WOS:000262602200006 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/64776 |
Collection | 北京大学第一临床医学院_儿科 |
作者单位 | 1.Peking Univ, Hosp 1, Ctr Lab, Beijing 100034, Peoples R China 2.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing, Peoples R China 3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China 4.Peking Univ, Hosp 1, Dept Electron Microscopy, Beijing 100034, Peoples R China |
Recommended Citation GB/T 7714 | Wang, Yanfei,Zhao, Xia,Jin, Hongfang,et al. Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2009,29(2):173-U71. |
APA | Wang, Yanfei.,Zhao, Xia.,Jin, Hongfang.,Wei, Hongling.,Li, Wei.,...&Du, Junbao.(2009).Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,29(2),173-U71. |
MLA | Wang, Yanfei,et al."Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 29.2(2009):173-U71. |
Files in This Item: | There are no files associated with this item. |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment