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学科主题临床医学
Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
Wang, Yanfei1; Zhao, Xia1; Jin, Hongfang1; Wei, Hongling1; Li, Wei1; Bu, Dingfang3; Tang, Xiuying4; Ren, Yali4; Tang, Chaoshu2; Du, Junbao1,2
关键词hydrogen sulfide intercellular adhesion molecule-1 atherosclerosis apolipoprotein E knockout mice human umbilical vein endothelial cells
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2009-02-01
DOI10.1161/ATVBAHA.108.179333
29期:2页:173-U71
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]E-DEFICIENT MICE ; CELL-ADHESION MOLECULES ; SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; LIFE-STYLE ; EXPRESSION ; INFLAMMATION ; INHIBITION ; HYPERCHOLESTEROLEMIA ; OXYGENASE
英文摘要

Objective-We explored the effect of hydrogen sulfide (H(2)S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE(-/-)) mice and human umbilical vein endothelial cells (HUVECs).

Methods and Results-ApoE(-/-) mice were treated with sodium hydrosulfide (NaHS) or DL-propargylglycine (PPG); HUVECs were pretreated with NaHS. Compared with control mice, apoE(-/-) mice showed decreased plasma H(2)S level and aortic H(2)S production but increased plasma ICAM-1 and aortic ICAM-1 protein and mRNA. Compared with apoE(-/-) mice, apoE(-/-) +NaHS mice showed increased plasma H(2)S level, but decreased size of atherosclerotic plaque and plasma and aortic ICAM-1 levels, whereas apoE(-/-) +PPG mice showed decreased plasma H(2)S level but enlarged plaque size and increased plasma and aortic ICAM-1 levels. NaHS suppressed ICAM-1 expression in tumor necrosis factor (TNF)-alpha-treated HUVECs. NaHS inhibited I kappa B degradation and NF-kappa B nuclear translocation in HUVECs treated with TNF-alpha.

Conclusions-The vascular CSE/H(2)S pathway was disturbed in apoE(-/-) mice. H(2)S exerted an antiatherogenic effect and inhibited ICAM-1 expression in apoE(-/-) mice. H(2)S inhibited ICAM-1 expression in TNF-alpha-induced HUVECs via the NF-kappa B pathway. (Arterioscler Thromb Vasc Biol. 2009; 29: 173-179.)

语种英语
WOS记录号WOS:000262602200006
项目编号30630031 ; 30571971 ; 30425010 ; 2006CB503807
资助机构National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program
引用统计
被引频次:171[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64776
专题北京大学第一临床医学院_儿科
北京大学第一临床医学院_电镜室
北京大学第三临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Ctr Lab, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Electron Microscopy, Beijing 100034, Peoples R China
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GB/T 7714
Wang, Yanfei,Zhao, Xia,Jin, Hongfang,et al. Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2009,29(2):173-U71.
APA Wang, Yanfei.,Zhao, Xia.,Jin, Hongfang.,Wei, Hongling.,Li, Wei.,...&Du, Junbao.(2009).Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,29(2),173-U71.
MLA Wang, Yanfei,et al."Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 29.2(2009):173-U71.
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