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学科主题: 临床医学
题名:
Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
作者: Wang, Yanfei1; Zhao, Xia1; Jin, Hongfang1; Wei, Hongling1; Li, Wei1; Bu, Dingfang3; Tang, Xiuying4; Ren, Yali4; Tang, Chaoshu2; Du, Junbao1,2
关键词: hydrogen sulfide ; intercellular adhesion molecule-1 ; atherosclerosis ; apolipoprotein E knockout mice ; human umbilical vein endothelial cells
刊名: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
发表日期: 2009-02-01
DOI: 10.1161/ATVBAHA.108.179333
卷: 29, 期:2, 页:173-U71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: E-DEFICIENT MICE ; CELL-ADHESION MOLECULES ; SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; LIFE-STYLE ; EXPRESSION ; INFLAMMATION ; INHIBITION ; HYPERCHOLESTEROLEMIA ; OXYGENASE
英文摘要:

Objective-We explored the effect of hydrogen sulfide (H(2)S) on atherosclerotic progression, particularly on intracellular adhesion molecule-1 (ICAM-1) in apolipoprotein-E knockout (apoE(-/-)) mice and human umbilical vein endothelial cells (HUVECs).

Methods and Results-ApoE(-/-) mice were treated with sodium hydrosulfide (NaHS) or DL-propargylglycine (PPG); HUVECs were pretreated with NaHS. Compared with control mice, apoE(-/-) mice showed decreased plasma H(2)S level and aortic H(2)S production but increased plasma ICAM-1 and aortic ICAM-1 protein and mRNA. Compared with apoE(-/-) mice, apoE(-/-) +NaHS mice showed increased plasma H(2)S level, but decreased size of atherosclerotic plaque and plasma and aortic ICAM-1 levels, whereas apoE(-/-) +PPG mice showed decreased plasma H(2)S level but enlarged plaque size and increased plasma and aortic ICAM-1 levels. NaHS suppressed ICAM-1 expression in tumor necrosis factor (TNF)-alpha-treated HUVECs. NaHS inhibited I kappa B degradation and NF-kappa B nuclear translocation in HUVECs treated with TNF-alpha.

Conclusions-The vascular CSE/H(2)S pathway was disturbed in apoE(-/-) mice. H(2)S exerted an antiatherogenic effect and inhibited ICAM-1 expression in apoE(-/-) mice. H(2)S inhibited ICAM-1 expression in TNF-alpha-induced HUVECs via the NF-kappa B pathway. (Arterioscler Thromb Vasc Biol. 2009; 29: 173-179.)

语种: 英语
所属项目编号: 30630031 ; 30571971 ; 30425010 ; 2006CB503807
项目资助者: National Natural Science Foundation of China ; National Science Fund for Distinguished Young Scholars ; Major Basic Research Program of China ; Chang Jiang Scholars Program
WOS记录号: WOS:000262602200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64776
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Ctr Lab, Beijing 100034, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Electron Microscopy, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Yanfei,Zhao, Xia,Jin, Hongfang,et al. Role of Hydrogen Sulfide in the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2009,29(2):173-U71.
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