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学科主题临床医学
Functional alpha(1)-adrenoceptor subtypes in human submandibular glands
Huang, Z; Wu, LL; Zhang, YY; Gao, Y; Yu, GY
关键词alpha(1)-adrenoceptor receptor subtypes neurotransmitter submandibular gland tissue distribution
刊名JOURNAL OF DENTAL RESEARCH
2006-03-01
85期:3页:251-256
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MESSENGER-RNA ; RECEPTOR STIMULATION ; SALIVARY-GLANDS ; ACINAR-CELLS ; RAT-TISSUES ; EXPRESSION ; CLONING ; MECHANISMS ; ADRENOCEPTORS ; ALPHA(1B)
英文摘要

alpha(1)-Adrenoceptor has been discovered to exist in many human tissues and mediates important physiological functions. The purpose of this study was to detect the expression, distribution, and function of alpha(1)-adrenoceptor subtypes in human submandibular glands. alpha(1A)-and alpha(1B)-Adrenoceptor mRNAs were identified by reverse-trans-cription/polymerase chain-reaction (RT-PCR), and their proteins were detected by Western blotting. No expression of the alpha(1D)-adrenoceptor mRNA and protein was found. By in situ hybridization and immunohistochemistry, alpha(1A)- and alpha(1B)-adrenoceptor mRNAs and proteins were shown to be widespread in both ductal and acinar cells. By confocal microscopy, phenylephrine (stimulating both alpha(1A)- and alpha(1B)-adrenoceptors) or A61603 (alpha(1A)-selective agonist) induced an increase in intracellular calcium by 2.33 +/- 0.18-fold and 1.81 +/- 0.43-fold, respectively, while 5-methylurapidil (alpha(1A)- selective antagonist) partly blocked calcium mobility stimulated by phenylephrine. The results indicated that functional alpha(1A)- and alpha(1B)-adrenoceptors were expressed in human submandibular glands, and might contribute to the regulation of saliva synthesis and secretion.

语种英语
WOS记录号WOS:000236588200009
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64782
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Pathophysiol, Beijing 100871, Peoples R China
2.Peking Univ, Third Hosp, Inst Vasc Med, Beijing 100871, Peoples R China
3.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Peking Univ, Dept Oral & Maxillofacial Surg, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Huang, Z,Wu, LL,Zhang, YY,et al. Functional alpha(1)-adrenoceptor subtypes in human submandibular glands[J]. JOURNAL OF DENTAL RESEARCH,2006,85(3):251-256.
APA Huang, Z,Wu, LL,Zhang, YY,Gao, Y,&Yu, GY.(2006).Functional alpha(1)-adrenoceptor subtypes in human submandibular glands.JOURNAL OF DENTAL RESEARCH,85(3),251-256.
MLA Huang, Z,et al."Functional alpha(1)-adrenoceptor subtypes in human submandibular glands".JOURNAL OF DENTAL RESEARCH 85.3(2006):251-256.
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