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学科主题: 临床医学
题名:
Adverse events of statin-fenofibric acid versus statin monotherapy: a meta-analysis of randomized controlled trials
作者: Geng, Qiang; Ren, Jingyi; Chen, Hong; Lee, Chongyou; Liang, Wenqing
关键词: Adverse events ; Fenofibric acid ; Meta-analysis ; Statin
刊名: CURRENT MEDICAL RESEARCH AND OPINION
发表日期: 2013-03-01
DOI: 10.1185/03007995.2013.766592
卷: 29, 期:3, 页:181-188
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]: General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]: MIXED DYSLIPIDEMIA ; COMBINED HYPERLIPIDEMIA ; COMBINATION ; EFFICACY ; SAFETY ; SIMVASTATIN ; ROSUVASTATIN ; PARTICIPANTS ; THERAPY ; PHASE-3
英文摘要:

Background:

Patients with mixed dyslipidemia can benefit from the combination of fenofibric acid (FA) with statins, but concerns about adverse events make physicians reluctant to prescribe the combination therapy.

Objective:

In the present study, we performed a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse events in patients taking statins and FA.

Methods:

Medline, Embase and the Cochrane Library were searched to identify studies that reported adverse events. Finally, five trials covering 2704 patients were selected in this study.

Results:

There were significant decreases in TG and increases in HDL-C in patients receiving combination therapy compared with statin monotherapy. The incidence of hepatic toxicity (OR, 3.57; 95% CI, 1.17-10.83; P<0.05) and increased creatinine (OR, 3.22; 95% CI, 1.28-8.11; P<0.05) was significantly higher in the FA+low-dose statin group than in the corresponding statin monotherapy. The incidence of CK elevations and muscle-associated AEs was not statistically different between the two groups. The adverse events in the FA+moderate-dose statin group were almost identical to those in the FA+low-dose statin group.

Conclusions:

In conclusion, combination therapy could improve the blood lipid profile. Addition of FA to statins therapy is more frequently associated with hepatic and renal toxicity than muscle-associated AEs. Therefore patients taking the combination of FA with statins should have liver enzyme and renal function monitored. However, we still need large-scale and long follow-up period RCTs to definitively confirm the adverse events of FA-statin therapy.

语种: 英语
所属项目编号: NSFC 30570712
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000314851000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64786
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Geng, Qiang,Ren, Jingyi,Chen, Hong,et al. Adverse events of statin-fenofibric acid versus statin monotherapy: a meta-analysis of randomized controlled trials[J]. CURRENT MEDICAL RESEARCH AND OPINION,2013,29(3):181-188.
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