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学科主题: 药学
题名:
Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking
作者: Xue, Xue1,2; Hall, Matthew D.3; Zhang, Qiang2; Wang, Paul C.4; Gottesman, Michael M.3; Liang, Xing-Jie1
关键词: cancer ; cisplatin ; drug resistance ; nanoscale drug delivery platforms ; membrane trafficking ; nanotechnology ; chemotherapy ; abnormal membrane proteins
刊名: ACS NANO
发表日期: 2013-12-01
DOI: 10.1021/nn405004f
卷: 7, 期:12, 页:10452-10464
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: PLGA-PEG NANOPARTICLES ; DNA-DAMAGING AGENTS ; CISPLATIN-RESISTANCE ; MULTIDRUG-RESISTANCE ; COPPER TRANSPORTER ; TUMOR-CELLS ; PT(IV) PRODRUG ; P-GLYCOPROTEIN ; BREAST-CANCER ; LUNG-CANCER
英文摘要:

The development of cellular resistance to platinum-based chemotherapies is often associated with reduced intracellular platinum concentrations. In some models, this reduction is due to abnormal membrane protein trafficking, resulting in reduced uptake by transporters at the cell surface. Given the central role of platinum drugs in the clinic, it is critical to overcome cisplatin resistance by bypassing the plasma membrane barrier to significantly increase the intracellular cisplatin concentration enough to inhibit the proliferation of cisplatin-resistant cells. Therefore, rational design of appropriate nanoscale drug delivery platforms (nDDPs) loaded with cisplatin or other platinum analogues as payloads is a possible strategy to solve this problem. This review will focus on the known mechanism of membrane trafficking in cisplatin-resistant cells and the development and employment of nDDPs to improve cell uptake of cisplatin.

语种: 英语
所属项目编号: 31225009 ; 2012BAF13B05 ; 81171455 ; 2009CB930200
项目资助者: National Natural Science Foundation for Distinguished Young Scholars of China ; National Science and Technology support program ; National Natural Science Foundation of China ; National Key Basic Research Program of China ; Chinese Academy of Sciences (CAS) "Hundred Talents Program" ; Intramural Research Program of the National Institutes of Health, National Cancer Institute
WOS记录号: WOS:000329137100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64801
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
3.NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
4.Howard Univ, Dept Radiol, Mol Imaging Lab, Washington, DC 20060 USA

Recommended Citation:
Xue, Xue,Hall, Matthew D.,Zhang, Qiang,et al. Nanoscale Drug Delivery Platforms Overcome Platinum-Based Resistance in Cancer Cells Due to Abnormal Membrane Protein Trafficking[J]. ACS NANO,2013,7(12):10452-10464.
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