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学科主题临床医学
The clinical impact of non-obstructive chronic bronchitis in current and former smokers
Martinez, Carlos H.1; Kim, Victor2; Chen, Yahong3; Kazerooni, Ella A.4; Murray, Susan5; Criner, Gerard J.2; Curtis, Jeffrey L.1,6; Regan, Elizabeth A.7; Wan, Emily8,9; Hersh, Craig P.8,9; Silverman, Edwin K.8,9; Crapo, James D.7; Martinez, Fernando J.1; Han, MeiLan K.1; COPDGene Investigators
关键词Cough Quality of life Gastroesophageal reflux Occupational exposure GERD Tobacco
刊名RESPIRATORY MEDICINE
2014-03-01
DOI10.1016/j.rmed.2013.11.003
108期:3页:491-499
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Respiratory System
研究领域[WOS]Cardiovascular System & Cardiology ; Respiratory System
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; QUALITY-OF-LIFE ; IMPORTANT DIFFERENCE ; SLEEP-APNEA ; RESPIRATORY QUESTIONNAIRE ; GENERAL-POPULATION ; YOUNG-ADULTS ; LUNG-CANCER ; COPD ; SYMPTOMS
英文摘要

Background: As the clinical significance of chronic bronchitis among smokers without airflow obstruction is unclear, we sought to determine morbidity associated with this disorder.

Methods: We examined subjects from the COPDGene study and compared those with FEV1 /FVC >= 0.70, no diagnosis of asthma and chronic bronchitis as defined as a history of cough and phlegm production for >= 3 months/year for >= 2 years (NCB) to non-obstructed subjects without chronic bronchitis (CB-). Multivariate analysis was used to determine factors associated with and impact of NCB.

Results: We identified 597 NCB and 4283 CB-subjects. NCB participants were younger (55.4 vs. 57.2 years, p < 0.001) with greater tobacco exposure (42.9 vs. 37.8 pack-years, p < 0.001) and more often current smokers; more frequently reported occupational exposure to fumes (52.8% vs. 42.2%, p < 0.001), dust for >= 1 year (55.3% vs. 42.0%, p < 0.001) and were less likely to be currently working. NCB subjects demonstrated worse quality-of-life (SGRQ 35.6 vs. 15.1, p < 0.001) and exercise capacity (walk distance 415 vs. 449 m, p < 0.001) and more frequently reported respiratory "flareups" requiring treatment with antibiotics or steroids (0.30 vs. 0.10 annual events/subject, p < 0.001) prior to enrollment and during follow-up (0.34 vs. 0.16 annual events/subject, p < 0.001). In multivariate analysis, current smoking, GERD, sleep apnea and occupational exposures were significantly associated with NCB.

Conclusions: While longitudinal data will be needed to determine whether NCB progresses to COPD, NCB patients have poorer quality-of-life, exercise capacity and frequent respiratory events. Beyond smoking cessation interventions, further research is warranted to determine the benefit of other therapeutics in this population. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000333489100009
项目编号U01HL089897 ; U01Hl089856 ; K23 HL093351 ; T32 HL007749-20 ; R01NR013377
资助机构NHLBI ; Biomedical Laboratory Research &amp ; Development Service, Department of Veterans Affairs ; NIH NHLBI ; NHLLBI
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64802
专题北京大学第三临床医学院_呼吸科
作者单位1.Univ Michigan Hlth Syst, Pulm & Crit Care Div, Ann Arbor, MI 48109 USA
2.Temple Univ, Sch Med, Div Pulm & Crit Care, Philadelphia, PA 19122 USA
3.Peking Univ, Resp Dept, Hosp 3, Beijing 100871, Peoples R China
4.VA Healthcare Syst, Med Serv, Ann Arbor, MI USA
5.Natl Jewish Med & Res Ctr, Dept Med, Denver, CO USA
6.Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
7.Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA
8.Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA
9.Brigham & Womens Hosp, Pulm & Crit Care Div, Boston, MA 02115 USA
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GB/T 7714
Martinez, Carlos H.,Kim, Victor,Chen, Yahong,et al. The clinical impact of non-obstructive chronic bronchitis in current and former smokers[J]. RESPIRATORY MEDICINE,2014,108(3):491-499.
APA Martinez, Carlos H..,Kim, Victor.,Chen, Yahong.,Kazerooni, Ella A..,Murray, Susan.,...&COPDGene Investigators.(2014).The clinical impact of non-obstructive chronic bronchitis in current and former smokers.RESPIRATORY MEDICINE,108(3),491-499.
MLA Martinez, Carlos H.,et al."The clinical impact of non-obstructive chronic bronchitis in current and former smokers".RESPIRATORY MEDICINE 108.3(2014):491-499.
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