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学科主题临床医学
The transport of alpha(1A)-adrenergic receptor with 33-nm step size in live cells
Liang, Zhang-Yi; Xu, Ning; Guan, Ying-Hua; Xu, Ming; He, Qi-Hua; Han, Qi-De; Zhang, You-Yi; Zhao, Xin-Sheng
关键词alpha(1A)-adrenergic receptor transport living cell actin real time single particle tracking myosin
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-02-09
DOI10.1016/j.bbrc.2006.11.116
353期:2页:231-237
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]PROTEIN-COUPLED RECEPTORS ; HAND-OVER-HAND ; MYOSIN-V ; ALPHA(1)-ADRENOCEPTOR SUBTYPES ; MEDIATED INTERNALIZATION ; ACTIN ; ALPHA(1B)-ADRENOCEPTOR ; DESENSITIZATION ; LOCALIZATION ; MECHANISM
英文摘要

We used the technique of single particle tracking (SPT) with high tempo-spatial resolution to efficiently explore the route and mechanism for the transport Of alpha(1A)-adrenergic receptor (alpha(1A)-AR) in real time in living cells. We found that the initial transport Of alpha(1A)-AR in cells depended on actin filaments with the velocity of 0.2 mu m/s and exhibited discrete 33-nm steps. It was noted that the step size, the rate constant, and the velocities were in accordance with the character of single myosin in vitro, implying that while transporting each endosome myosins did not work in the "tug-of-war" mode and that they did not adopt the strategy to boost up transporting speed by working coordinately. These results provided insight into the mechanism of GPCR transport ill vivo. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000243543100003
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64803
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
3.Peking Univ, Dept Biol Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
4.Peking Univ Third Hosp, Inst Vasc Med, Beijing 100083, Peoples R China
5.Peking Univ, Ctr Med Anal, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Liang, Zhang-Yi,Xu, Ning,Guan, Ying-Hua,et al. The transport of alpha(1A)-adrenergic receptor with 33-nm step size in live cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,353(2):231-237.
APA Liang, Zhang-Yi.,Xu, Ning.,Guan, Ying-Hua.,Xu, Ming.,He, Qi-Hua.,...&Zhao, Xin-Sheng.(2007).The transport of alpha(1A)-adrenergic receptor with 33-nm step size in live cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,353(2),231-237.
MLA Liang, Zhang-Yi,et al."The transport of alpha(1A)-adrenergic receptor with 33-nm step size in live cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 353.2(2007):231-237.
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