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学科主题: 临床医学
题名:
Capillary Remodeling and Collateral Growth Without Angiogenesis After Unilateral Common Carotid Artery Occlusion in Mice
作者: Guo, Huailian2; Itoh, Yoshiaki1; Toriumi, Haruki; Yamada, Satoshi; Tomita, Yutaka; Hoshino, Haruhiko; Suzuki, Norihiro
关键词: carotid artery occlusion ; capillary remodeling ; Tie2 ; endothelial cell ; collateral artery
刊名: MICROCIRCULATION
发表日期: 2011
DOI: 10.1111/j.1549-8719.2011.00081.x
卷: 18, 期:3, 页:221-227
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: RECEPTOR TYROSINE KINASE ; ISCHEMIC BRAIN ; BLOOD-FLOW ; STROKE ; RATS ; EXPRESSION ; HYPOXIA ; GENES ; MICROCIRCULATION ; HEMODYNAMICS
英文摘要:

P>Objective:

To clarify the mechanisms of blood flow restoration after major artery occlusion, we presented first dynamic changes in cortical vessel morphology observed through a cranial window in mice after unilateral common carotid artery (CCA) occlusion.

Methods:

The density and diameter of capillaries, as well as diameters of pial arteries, were measured by confocal laser-scanning microscopy and fluorescent microscopy, respectively. Possible angiogenesis was evaluated by detecting any outgrowth of endothelial cells from pre-existing vessels or intussusception in Tie2-GFP mice.

Results:

Immediately after unilateral CCA occlusion, cerebral blood flow (CBF) index, the reciprocal of mean transit time, reduced significantly and returned to the previous level after 14 days. Repeated observation of the cortical vessels did not reveal any angiogenesis, whereas the cortical capillary diameter increased by 74% after 14 days. The anterior cerebral artery (ACA) and collateral vessels connecting ACA and middle cerebral artery also dilated significantly. The capillary dilatation to the size of arteriole in the settings of collateral growth and CBF restoration suggested capillary remodeling.

Conclusions:

Our results indicate that capillary remodeling, pial artery dilatation and collateral growth without angiogenesis are sufficient mechanisms to restore normal cerebral blood flow after unilateral CCA occlusion.

语种: 英语
所属项目编号: 17390255
项目资助者: Japanese Ministry of Education, Culture, Sports, Science and Technology
WOS记录号: WOS:000288759900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64805
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Keio Univ, Sch Med, Dept Neurol, Shinjuku Ku, Tokyo 1608582, Japan
2.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100871, Peoples R China

Recommended Citation:
Guo, Huailian,Itoh, Yoshiaki,Toriumi, Haruki,et al. Capillary Remodeling and Collateral Growth Without Angiogenesis After Unilateral Common Carotid Artery Occlusion in Mice[J]. MICROCIRCULATION,2011,18(3):221-227.
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