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Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells
Baek, Seung Hoon; Piao, Xiang Lan; Lee, Un Jo; Kim, Hyun Young; Park, Jeong Hill
关键词ginsenoside cisplatin-induced nephrotoxicity LLC-PK1 processed ginseng
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2006-10-01
29期:10页:2051-2055
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]DAMMARANE GLYCOSIDES ; RD
英文摘要

Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh-4 and Rk(3) significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.

语种英语
WOS记录号WOS:000241546600013
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64821
专题北京大学药学院
作者单位1.Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Baek, Seung Hoon,Piao, Xiang Lan,Lee, Un Jo,et al. Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(10):2051-2055.
APA Baek, Seung Hoon,Piao, Xiang Lan,Lee, Un Jo,Kim, Hyun Young,&Park, Jeong Hill.(2006).Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,29(10),2051-2055.
MLA Baek, Seung Hoon,et al."Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 29.10(2006):2051-2055.
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