北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells
作者: Baek, Seung Hoon; Piao, Xiang Lan; Lee, Un Jo; Kim, Hyun Young; Park, Jeong Hill
关键词: ginsenoside ; cisplatin-induced nephrotoxicity ; LLC-PK1 ; processed ginseng
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2006-10-01
卷: 29, 期:10, 页:2051-2055
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: DAMMARANE GLYCOSIDES ; RD
英文摘要:

Ginsenosides, the unique constituents and secondary metabolites of the Panax species, have been known to be the pharmacologically active ingredients of ginseng. Recently, our research group has developed a new processed ginseng, called Sun ginseng (SG), which has an increased amount of the red ginseng unique ginsenosides (RGUG). In our previous studies, this new processed ginseng reduced cisplatin-induced nephrotoxicity more than white ginseng in both in vitro and in vivo systems. In this study, we isolated and characterized active principles through activity-guided fractionation. Ginsenosides Rh-4 and Rk(3) significantly reduced the cisplatin-induced nephrotoxicity in LLC-PK1 cells in a dose-dependent manner. The mechanisms of function and structure-activity relationships with other ginsenosides remain for further investigation.

语种: 英语
WOS记录号: WOS:000241546600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64821
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 151742, South Korea
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Baek, Seung Hoon,Piao, Xiang Lan,Lee, Un Jo,et al. Reduction of cisplatin-induced nephrotoxicity by ginsenosides isolated from processed ginseng in cultured renal tubular cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2006,29(10):2051-2055.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Baek, Seung Hoon]'s Articles
[Piao, Xiang Lan]'s Articles
[Lee, Un Jo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Baek, Seung Hoon]‘s Articles
[Piao, Xiang Lan]‘s Articles
[Lee, Un Jo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace