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Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury
Feng, Dechun2; Wang, Ying1; Mei, Yunhua1; Xu, Yan2; Xu, Heng2; Lu, Yun2; Luo, Qingqiong1; Zhou, Shupei3; Kong, Xiangyin2; Xu, Lingyun1,2
关键词concanavalin A-induced hepatitis stearoyl-CoA desaturase 1 lipid accumulation leptin STAT1
刊名LABORATORY INVESTIGATION
2009-02-01
DOI10.1038/labinvest.2008.105
89期:2页:222-230
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pathology
研究领域[WOS]Research & Experimental Medicine ; Pathology
关键词[WOS]NECROSIS-FACTOR-ALPHA ; FACTOR-KAPPA-B ; CONCANAVALIN-A ; HEPATIC STEATOSIS ; GENE-EXPRESSION ; T-CELLS ; MOUSE ; INFLAMMATION ; LEPTIN ; ACTIVATION
英文摘要

Immunity and metabolism are closely linked. The liver is an important metabolic organ in the body. However, the interactions between hepatocytes and the immune system are poorly understood. In mice developing concanavalin A ( ConA)-induced hepatitis (CIH), we found extensive lipid accumulation in hepatocytes. Critical enzyme involved in fat synthesis such as stearoyl-CoA desaturase 1 (SCD1) was upregulated. When we injected ConA to SCD1-deficient mice, we found these mice to be highly resistant to CIH. The mechanisms of the protective effect of SCD1 deficiency might be attributed to the reduced leptin levels in those mice, which modulated critical cytokines and signaling pathways in CIH pathogenesis. In conclusion, our study suggests that SCD1 deficiency protects mice from liver injury in a leptin-dependent manner. Laboratory Investigation ( 2009) 89, 222-230; doi:10.1038/labinvest.2008.105; published online 10 November 2008

语种英语
WOS记录号WOS:000262866700010
项目编号30671994 ; J0171-1905
资助机构National Foundation of Natural Science ; Chinese Academy of Sciences
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64823
专题实验动物科学部
作者单位1.Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Shanghai Inst Biol Sci,Inst Hlth Sci, Shanghai 200025, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100871, Peoples R China
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GB/T 7714
Feng, Dechun,Wang, Ying,Mei, Yunhua,et al. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury[J]. LABORATORY INVESTIGATION,2009,89(2):222-230.
APA Feng, Dechun.,Wang, Ying.,Mei, Yunhua.,Xu, Yan.,Xu, Heng.,...&Xu, Lingyun.(2009).Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.LABORATORY INVESTIGATION,89(2),222-230.
MLA Feng, Dechun,et al."Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury".LABORATORY INVESTIGATION 89.2(2009):222-230.
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