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学科主题: 实验动物
题名:
Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury
作者: Feng, Dechun2; Wang, Ying1; Mei, Yunhua1; Xu, Yan2; Xu, Heng2; Lu, Yun2; Luo, Qingqiong1; Zhou, Shupei3; Kong, Xiangyin2; Xu, Lingyun1,2
关键词: concanavalin A-induced hepatitis ; stearoyl-CoA desaturase 1 ; lipid accumulation ; leptin ; STAT1
刊名: LABORATORY INVESTIGATION
发表日期: 2009-02-01
DOI: 10.1038/labinvest.2008.105
卷: 89, 期:2, 页:222-230
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pathology
研究领域[WOS]: Research & Experimental Medicine ; Pathology
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; FACTOR-KAPPA-B ; CONCANAVALIN-A ; HEPATIC STEATOSIS ; GENE-EXPRESSION ; T-CELLS ; MOUSE ; INFLAMMATION ; LEPTIN ; ACTIVATION
英文摘要:

Immunity and metabolism are closely linked. The liver is an important metabolic organ in the body. However, the interactions between hepatocytes and the immune system are poorly understood. In mice developing concanavalin A ( ConA)-induced hepatitis (CIH), we found extensive lipid accumulation in hepatocytes. Critical enzyme involved in fat synthesis such as stearoyl-CoA desaturase 1 (SCD1) was upregulated. When we injected ConA to SCD1-deficient mice, we found these mice to be highly resistant to CIH. The mechanisms of the protective effect of SCD1 deficiency might be attributed to the reduced leptin levels in those mice, which modulated critical cytokines and signaling pathways in CIH pathogenesis. In conclusion, our study suggests that SCD1 deficiency protects mice from liver injury in a leptin-dependent manner. Laboratory Investigation ( 2009) 89, 222-230; doi:10.1038/labinvest.2008.105; published online 10 November 2008

语种: 英语
所属项目编号: 30671994 ; J0171-1905
项目资助者: National Foundation of Natural Science ; Chinese Academy of Sciences
WOS记录号: WOS:000262866700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64823
Appears in Collections:实验动物科学部_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Shanghai 200025, Peoples R China
2.Shanghai Jiao Tong Univ, Chinese Acad Sci, Sch Med, Shanghai Inst Biol Sci,Inst Hlth Sci, Shanghai 200025, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100871, Peoples R China

Recommended Citation:
Feng, Dechun,Wang, Ying,Mei, Yunhua,et al. Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury[J]. LABORATORY INVESTIGATION,2009,89(2):222-230.
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