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Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats
Li, XH; Du, JB; Shi, L; Li, J; Tian, XY; Qi, JG; Wei, B; Jin, HF; Tang, CS
关键词high pulmonary blood flow hydrogen sulfide pulmonary hypertension pulmonary vascular structural remodeling
刊名CIRCULATION JOURNAL
2005-11-01
69期:11页:1418-1424
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]NITRIC-OXIDE SYNTHASE ; HEME OXYGENASE-1 ; HYPOXIA ; NEUROMODULATOR ; EXPRESSION ; H2S
英文摘要

Background The mechanisms responsible for the development of pulmonary hypertension (PH) and pulmonary vascular structural remodeling induced by high pulmonary blood flow are not fully understood. The present study was designed to explore the possible changes in endogenous hydrogen sulfide (H2S), a novel gasotransmitter, on the pathogenesis of PH and pulmonary vascular structural remodeling induced by high pulmonary blood flow.

Methods and Results Twenty-two male Sprague-Dawley rats were randomly divided into a shunting group (n=11) and control group (n=11). Rats in the shunting group underwent an abdominal aorta-inferior cava vein shunting operation. After 11 weeks of shunting, the plasma level of H2S and lung tissue H2S producing rate were much lower than those of the control group (p<0.01). In situ hybridization analysis showed that the expression of cystathionine gamma-lyase (CSE) mRNA was down-regulated in the pulmonary arteries of the shunting rats compared with the control group (p<0.01), and competitive quantitative reverse transcription-polymerase chain reaction showed that the relative amount of CSEmRNA in lung tissue was decreased significantly (p<0.01).

Conclusions The endogenous H2S pathway is down-regulated in PH and pulmonary vascular structural remodeling is induced by high pulmonary blood flow.

语种英语
WOS记录号WOS:000232900100021
引用统计
被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64827
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Minist Educ, Lab Mol Cardiovasc Sci, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, XH,Du, JB,Shi, L,et al. Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats[J]. CIRCULATION JOURNAL,2005,69(11):1418-1424.
APA Li, XH.,Du, JB.,Shi, L.,Li, J.,Tian, XY.,...&Tang, CS.(2005).Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats.CIRCULATION JOURNAL,69(11),1418-1424.
MLA Li, XH,et al."Down-regulation of endogenous hydrogen sulfide pathway in pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow in rats".CIRCULATION JOURNAL 69.11(2005):1418-1424.
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