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Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease
Wang, Guan-Nan1,2; Reinkensmeier, Gabriele3; Zhang, Si-Wei1,2; Zhou, Jian1,2; Zhang, Liang-Ren1,2; Zhang, Li-He1,2; Butters, Terry D.3; Ye, Xin-Shan1,2
刊名JOURNAL OF MEDICINAL CHEMISTRY
2009-05-28
DOI10.1021/jm801506m
52期:10页:3146-3149
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]LYSOSOMAL STORAGE DISORDERS ; ACID BETA-GLUCOSIDASE ; JEWISH PATIENTS ; INHIBITORS ; DERIVATIVES ; MUTATIONS ; MIGLUSTAT ; INCREASE
英文摘要

Highly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wildtype beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S).

语种英语
WOS记录号WOS:000266296200003
资助机构National Natural Science Foundafion of China ; Ministry of Science and Technology of China ; Oxford Glycobiology Institute
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64829
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Univ Oxford, Dept Biochem, Glycobiol Inst, Oxford OX1 3QU, England
推荐引用方式
GB/T 7714
Wang, Guan-Nan,Reinkensmeier, Gabriele,Zhang, Si-Wei,et al. Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease[J]. JOURNAL OF MEDICINAL CHEMISTRY,2009,52(10):3146-3149.
APA Wang, Guan-Nan.,Reinkensmeier, Gabriele.,Zhang, Si-Wei.,Zhou, Jian.,Zhang, Liang-Ren.,...&Ye, Xin-Shan.(2009).Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease.JOURNAL OF MEDICINAL CHEMISTRY,52(10),3146-3149.
MLA Wang, Guan-Nan,et al."Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease".JOURNAL OF MEDICINAL CHEMISTRY 52.10(2009):3146-3149.
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