北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease
 E tadataFieldValue">Wang, Guan-Nan1,2; Reinkensmeier, Gabriele3; Zhang, Si-Wei1,2; Zhou, Jian1,2; Zhang, Liang-Ren1,2; Zhang, Li-He1,2; Butters, Terry D.3; Ye, Xin-Shan1,2
刊名: JOURNAL OF MEDICINAL CHEMISTRY
发表日期: 2009-05-28
DOI: 10.1021/jm801506m
卷: 52, 期:10, 页:3146-3149
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: LYSOSOMAL STORAGE DISORDERS ; ACID BETA-GLUCOSIDASE ; JEWISH PATIENTS ; INHIBITORS ; DERIVATIVES ; MUTATIONS ; MIGLUSTAT ; INCREASE
英文摘要:

Highly potent N-substituted delta-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wildtype beta-glucocerebrosidase but 3- to 6-fold increases in mutant enzyme activity (N370S).

语种: 英语
项目资助者: National Natural Science Foundafion of China ; Ministry of Science and Technology of China ; Oxford Glycobiology Institute
WOS记录号: WOS:000266296200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64829
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Univ Oxford, Dept Biochem, Glycobiol Inst, Oxford OX1 3QU, England

Recommended Citation:
Wang, Guan-Nan,Reinkensmeier, Gabriele,Zhang, Si-Wei,et al. Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease[J]. JOURNAL OF MEDICINAL CHEMISTRY,2009,52(10):3146-3149.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Guan-Nan]'s Articles
[Reinkensmeier, Gabriele]'s Articles
[Zhang, Si-Wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Guan-Nan]‘s Articles
[Reinkensmeier, Gabriele]‘s Articles
[Zhang, Si-Wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace