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学科主题基础医学
Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene
Irwin, David M.1; Tan, Huanran2
关键词glucokinase gene duplication hexokinase gene evolution
刊名COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
2008-03-01
DOI10.1016/j.cbd.2007.11.002
3期:1页:96-107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]C-TERMINAL HALVES ; GLUCOSE PHOSPHORYLATING ISOENZYMES ; HUMAN GLUCOKINASE GENE ; BETA-CELL GLUCOKINASE ; RAT-BRAIN HEXOKINASE ; MAMMALIAN HEXOKINASES ; FUNCTIONAL-ORGANIZATION ; DEVELOPMENTAL EXPRESSION ; CATALYTIC-ACTIVITY ; SUGAR SPECIFICITY
英文摘要

Hexokinases (HK) phosphorylate sugar immediately upon its entry into cells allowing these sugars to be metabolized. A total of four hexokinases have been characterized in a diversity of vertebrates-HKI, HKII, HKIII, and HKIV HKIV is often called glucokinase (GCK) and has half the molecular weight of the other hexokinases, as it only has one hexokinase domain, while other vertebrate HKs have two. Differing hypothesis has been proposed to explain the diversification of the hexokinase gene family. We used a genomic approach to characterize hexokinase genes in a diverse array of vertebrate species and close relatives. Surprisingly we identified a fifth hexokinase-like gene, HKDC1 that exists and is expressed in diverse vertebrates. Analysis of the amino acid sequence of HKDC1 suggests that it may function as a hexokinase. To understand the evolution of the vertebrate hexokinase gene family we established a phylogeny of the hexokinase domain in all of the vertebrate hexokinase genes, as well as hexokinase genes from close relatives of the vertebrates. Our phylogeny demonstrates that duplication of the hexokinase domain, yielding a HK with two hexokinase domains, occurred prior to the diversification of the hexokinase gene family. We also establish that GCK evolved from a two hexokinase domain-containing gene, but has lost its N-terminal hexokinase domain. We also show that parallel changes in enzymatic function of HKI and HKIII have occurred. (C) 2007 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000254422700009
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64830
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1L5, Canada
2.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China
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Irwin, David M.,Tan, Huanran. Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2008,3(1):96-107.
APA Irwin, David M.,&Tan, Huanran.(2008).Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,3(1),96-107.
MLA Irwin, David M.,et al."Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 3.1(2008):96-107.
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