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学科主题: 临床医学
题名:
miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6
作者: Chen, Jingwen1,2; Wang, Miao2; Guo, Mingzhou3; Xie, Yuntao4; Cong, Yu-Sheng2
刊名: PLOS ONE
发表日期: 2013-11-25
DOI: 10.1371/journal.pone.0080266
卷: 8, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DNA-DAMAGE ; BREAST-CANCER ; IN-VIVO ; EXPRESSION ; MIR-433 ; P53 ; MICRORNA-127 ; PROTEIN
英文摘要:

Cellular senescence occurs as a response to extracellular and intracellular stresses and contributes to aging and age-related pathologies. Emerging evidence suggests that cellular senescence also acts as a potent tumor suppression mechanism that prevents the oncogenic transformation of primary human cells. Recent reports have indicated that miRNAsact as key modulators of cellular senescence by targeting critical regulators of the senescence pathways. We previously reported that miR-127 is up-regulated in senescent fibroblasts. In this report, we identified miR-127 as a novel regulator of cellular senescence that directly targets BCL6. We further showed that miR-127 is down-regulated in breast cancer tissuesand that this down-regulation is associated with up-regulation of BCL6. Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation. Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6.

语种: 英语
所属项目编号: 2012CB911203 ; 2010CB912802 ; 31201038 ; 31071200 ; 31171320
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000327543500031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64832
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Beijing Normal Univ, Coll Life Sci, Inst Cell Biol, Minist Educ,Key Lab Cell Proliferat & Regulat Bio, Beijing 100875, Peoples R China
2.Hangzhou Normal Univ, Sch Med, Inst Aging Res, Hangzhou, Zhejiang, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China
4.Peking Univ, Canc Hosp, Beijing Canc Hosp & Inst, Breast Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Jingwen,Wang, Miao,Guo, Mingzhou,et al. miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6[J]. PLOS ONE,2013,8(11).
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