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miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6
Chen, Jingwen1,2; Wang, Miao2; Guo, Mingzhou3; Xie, Yuntao4; Cong, Yu-Sheng2
刊名PLOS ONE
2013-11-25
DOI10.1371/journal.pone.0080266
8期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DNA-DAMAGE ; BREAST-CANCER ; IN-VIVO ; EXPRESSION ; MIR-433 ; P53 ; MICRORNA-127 ; PROTEIN
英文摘要

Cellular senescence occurs as a response to extracellular and intracellular stresses and contributes to aging and age-related pathologies. Emerging evidence suggests that cellular senescence also acts as a potent tumor suppression mechanism that prevents the oncogenic transformation of primary human cells. Recent reports have indicated that miRNAsact as key modulators of cellular senescence by targeting critical regulators of the senescence pathways. We previously reported that miR-127 is up-regulated in senescent fibroblasts. In this report, we identified miR-127 as a novel regulator of cellular senescence that directly targets BCL6. We further showed that miR-127 is down-regulated in breast cancer tissuesand that this down-regulation is associated with up-regulation of BCL6. Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation. Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6.

语种英语
WOS记录号WOS:000327543500031
项目编号2012CB911203 ; 2010CB912802 ; 31201038 ; 31071200 ; 31171320
资助机构National Basic Research Program of China ; National Natural Science Foundation of China
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64832
专题北京大学临床肿瘤学院
作者单位1.Beijing Normal Univ, Coll Life Sci, Inst Cell Biol, Minist Educ,Key Lab Cell Proliferat & Regulat Bio, Beijing 100875, Peoples R China
2.Hangzhou Normal Univ, Sch Med, Inst Aging Res, Hangzhou, Zhejiang, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China
4.Peking Univ, Canc Hosp, Beijing Canc Hosp & Inst, Breast Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Chen, Jingwen,Wang, Miao,Guo, Mingzhou,et al. miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6[J]. PLOS ONE,2013,8(11).
APA Chen, Jingwen,Wang, Miao,Guo, Mingzhou,Xie, Yuntao,&Cong, Yu-Sheng.(2013).miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6.PLOS ONE,8(11).
MLA Chen, Jingwen,et al."miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6".PLOS ONE 8.11(2013).
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