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学科主题: 医学信息学
题名:
Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration
作者: Li, Tingting1,2; Wan, Bingbing3; Huang, Jian3,4; Zhang, Xuegong2
关键词: Hepatocellular carcinoma ; Liver development ; Liver regeneration ; Microarray ; Functional preference ; Transcriptional regulation
刊名: MOLECULAR GENETICS AND GENOMICS
发表日期: 2010-05-01
DOI: 10.1007/s00438-010-0530-y
卷: 283, 期:5, 页:485-492
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]: HUMAN BREAST-CANCER ; TUMOR-SUPPRESSOR ; PROSTATE-CANCER ; IN-VIVO ; PROTEINS ; PATTERNS ; INVASION ; GROWTH ; S100A8 ; OVEREXPRESSION
英文摘要:

Proliferation of liver cells can be observed in hepatocarcinogenesis, at different stages of liver development, and during liver regeneration after an injury. Does it imply that they share similar molecular mechanisms? Here, the transcriptional profiles of hepatocellular carcinoma (HCC), liver development, and liver regeneration were systematically compared as a preliminary attempt to answer this question. From the comparison, we found that advanced HCC mimics early development in terms of deprived normal liver functions and activated cellular proliferation, but advanced HCC and early development differ in expressions of cancer-related genes and their transcriptional controls. HCC and liver regeneration demonstrate different expression patterns as a whole, but regeneration is similar to dysplasia (pre-stage of HCC) in terms of their proximity to the normal state. In summary, of these three important processes, the carcinogenic progress carries the highest variance in expression; HCC pre-stage shares some resemblance with liver regeneration; and advanced HCC stage displays similarity with early development.

语种: 英语
所属项目编号: 30625012 ; 60721003 ; 60905014 ; 2006CB910402 ; 08JC14164 ; 20070420097 ; 07R214138
项目资助者: NSFC ; Tsinghua University ; Chinese National Key Program on Basic Research ; Shanghai Commission for Science and Technology ; China Postdoctoral Science Foundation ; Shanghai Postdoctoral Science Foundation
WOS记录号: WOS:000276661600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64837
Appears in Collections:基础医学院_医学信息学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biomed Informat, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Tsinghua Univ, TNLIST Dept Automat, MOE Key Lab Bioinformat & Bioinformat Div, Beijing 100084, Peoples R China
3.Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China
4.Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China

Recommended Citation:
Li, Tingting,Wan, Bingbing,Huang, Jian,et al. Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration[J]. MOLECULAR GENETICS AND GENOMICS,2010,283(5):485-492.
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