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学科主题医学信息学
Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration
Li, Tingting1,2; Wan, Bingbing3; Huang, Jian3,4; Zhang, Xuegong2
关键词Hepatocellular carcinoma Liver development Liver regeneration Microarray Functional preference Transcriptional regulation
刊名MOLECULAR GENETICS AND GENOMICS
2010-05-01
DOI10.1007/s00438-010-0530-y
283期:5页:485-492
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]HUMAN BREAST-CANCER ; TUMOR-SUPPRESSOR ; PROSTATE-CANCER ; IN-VIVO ; PROTEINS ; PATTERNS ; INVASION ; GROWTH ; S100A8 ; OVEREXPRESSION
英文摘要

Proliferation of liver cells can be observed in hepatocarcinogenesis, at different stages of liver development, and during liver regeneration after an injury. Does it imply that they share similar molecular mechanisms? Here, the transcriptional profiles of hepatocellular carcinoma (HCC), liver development, and liver regeneration were systematically compared as a preliminary attempt to answer this question. From the comparison, we found that advanced HCC mimics early development in terms of deprived normal liver functions and activated cellular proliferation, but advanced HCC and early development differ in expressions of cancer-related genes and their transcriptional controls. HCC and liver regeneration demonstrate different expression patterns as a whole, but regeneration is similar to dysplasia (pre-stage of HCC) in terms of their proximity to the normal state. In summary, of these three important processes, the carcinogenic progress carries the highest variance in expression; HCC pre-stage shares some resemblance with liver regeneration; and advanced HCC stage displays similarity with early development.

语种英语
WOS记录号WOS:000276661600007
项目编号30625012 ; 60721003 ; 60905014 ; 2006CB910402 ; 08JC14164 ; 20070420097 ; 07R214138
资助机构NSFC ; Tsinghua University ; Chinese National Key Program on Basic Research ; Shanghai Commission for Science and Technology ; China Postdoctoral Science Foundation ; Shanghai Postdoctoral Science Foundation
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64837
专题北京大学基础医学院_医学信息学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Biomed Informat, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Tsinghua Univ, TNLIST Dept Automat, MOE Key Lab Bioinformat & Bioinformat Div, Beijing 100084, Peoples R China
3.Chinese Natl Human Genome Ctr Shanghai, Shanghai 201203, Peoples R China
4.Natl Engn Ctr Biochip Shanghai, Shanghai 201203, Peoples R China
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GB/T 7714
Li, Tingting,Wan, Bingbing,Huang, Jian,et al. Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration[J]. MOLECULAR GENETICS AND GENOMICS,2010,283(5):485-492.
APA Li, Tingting,Wan, Bingbing,Huang, Jian,&Zhang, Xuegong.(2010).Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration.MOLECULAR GENETICS AND GENOMICS,283(5),485-492.
MLA Li, Tingting,et al."Comparison of gene expression in hepatocellular carcinoma, liver development, and liver regeneration".MOLECULAR GENETICS AND GENOMICS 283.5(2010):485-492.
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