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Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere
Yang, Xiaoming; Zou, Xiaomin; Fu, Yiqiu; Mou, Ke; Fu, Gang; Ma, Chao; Xu, Ping
关键词hydroxyethylene dipeptide isostere peptidomimetics beta-secretase synthesis
刊名SYNTHETIC COMMUNICATIONS
2007
DOI10.1080/00397910600977509
37期:1-3页:9-24
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]STRUCTURE-BASED DESIGN ; ALPHA-AMINO ALDEHYDES ; STEREOSELECTIVE SYNTHESIS ; PROTEASE INHIBITORS ; ALZHEIMERS-DISEASE ; ACID
英文摘要

b-Secretase inhibitors with a Leu*Ala hydroxyethylene dipeptide (HED) isostere have been an especially interesting topic in recent years. In this study, a template compound 17 was synthesized, featuring truncation at the P-2 position and changes at P-2 and P-3, which differs from other reported potent inhibitors. The purpose was to explore optimal reaction conditions and construct an inhibitor library to investigate ideal protein-substrate interaction.

语种英语
WOS记录号WOS:000247620200001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64838
专题北京大学药学院_药物化学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drug, Dept Med Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Xiaoming,Zou, Xiaomin,Fu, Yiqiu,et al. Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere[J]. SYNTHETIC COMMUNICATIONS,2007,37(1-3):9-24.
APA Yang, Xiaoming.,Zou, Xiaomin.,Fu, Yiqiu.,Mou, Ke.,Fu, Gang.,...&Xu, Ping.(2007).Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere.SYNTHETIC COMMUNICATIONS,37(1-3),9-24.
MLA Yang, Xiaoming,et al."Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere".SYNTHETIC COMMUNICATIONS 37.1-3(2007):9-24.
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