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IR@PKUHSC  > 北京大学药学院  > 药物化学系  > 期刊论文
学科主题: 药学
题名:
Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere
作者: Yang, Xiaoming; Zou, Xiaomin; Fu, Yiqiu; Mou, Ke; Fu, Gang; Ma, Chao; Xu, Ping
关键词: hydroxyethylene dipeptide isostere ; peptidomimetics ; beta-secretase ; synthesis
刊名: SYNTHETIC COMMUNICATIONS
发表日期: 2007
DOI: 10.1080/00397910600977509
卷: 37, 期:1-3, 页:9-24
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: STRUCTURE-BASED DESIGN ; ALPHA-AMINO ALDEHYDES ; STEREOSELECTIVE SYNTHESIS ; PROTEASE INHIBITORS ; ALZHEIMERS-DISEASE ; ACID
英文摘要:

b-Secretase inhibitors with a Leu*Ala hydroxyethylene dipeptide (HED) isostere have been an especially interesting topic in recent years. In this study, a template compound 17 was synthesized, featuring truncation at the P-2 position and changes at P-2 and P-3, which differs from other reported potent inhibitors. The purpose was to explore optimal reaction conditions and construct an inhibitor library to investigate ideal protein-substrate interaction.

语种: 英语
WOS记录号: WOS:000247620200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64838
Appears in Collections:北京大学药学院_药物化学系_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drug, Dept Med Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Yang, Xiaoming,Zou, Xiaomin,Fu, Yiqiu,et al. Synthesis of beta-secretase inhibitors containing a hydroxyethylene dipeptide isostere[J]. SYNTHETIC COMMUNICATIONS,2007,37(1-3):9-24.
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