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学科主题临床医学
The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats
Xu, Fei1,2; Zhang, Bingxi2; Li, Tianzuo2
关键词local anesthetics neurotoxicity post partum spinal anesthesia
刊名FUNDAMENTAL & CLINICAL PHARMACOLOGY
2013-08-01
DOI10.1111/j.1472-8206.2012.01034.x
27期:4页:427-433
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]INDUCED CONDUCTION BLOCKADE ; RABBIT VAGUS NERVE ; SYSTEMIC TOXICITY ; PREGNANT EWES ; IN-VITRO ; BUPIVACAINE ; LEVOBUPIVACAINE ; ROPIVACAINE ; INCREASES ; INFUSION
英文摘要

During the perinatal period, the pharmacokinetics and pharmacodynamics of drugs may be altered. Data about the neurotoxicity of intrathecal local anesthetics in the peripartum period are lacking. So we hypothesized that the neurotoxicity of intrathecal lidocaine during perinatal period may be changed. Therefore, we designed the present study to determine whether the neurotoxicity of intrathecal lidocaine in postpartum rats would be different from that in nonpregnant, virgin rats. Postpartum and nonpregnant rats randomly received an intrathecal infusion of lidocaine 50mg/mL in saline, lidocaine 20mg/mL in saline, or saline for 1h at a rate of 1L/min. Four days after drug infusion, the rats were assessed for persistent impairment of sensory and motor function (MF) using the tail-flick (TF) test, paw pressure test, and MF score. Spinal cords and nerve roots were obtained for light and electron microscopic examinations, and the injury scores were compared between groups. The TF latencies and the mean nerve injury scores of the postpartum group were significantly higher than those of nonpregnant group. Lidocaine induced a dose-dependent impairment in TF latencies and nerve injury scores. There was no significant interaction between postpartum and the drug. Our results suggest that the neurotoxicity of intrathecal lidocaine is enhanced in rats during the early postpartum period compared with nonpregnant, virgin rats.

语种英语
WOS记录号WOS:000320775400010
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64839
专题北京大学第三临床医学院_麻醉科
作者单位1.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Affiliated Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China
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GB/T 7714
Xu, Fei,Zhang, Bingxi,Li, Tianzuo. The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats[J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY,2013,27(4):427-433.
APA Xu, Fei,Zhang, Bingxi,&Li, Tianzuo.(2013).The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats.FUNDAMENTAL & CLINICAL PHARMACOLOGY,27(4),427-433.
MLA Xu, Fei,et al."The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats".FUNDAMENTAL & CLINICAL PHARMACOLOGY 27.4(2013):427-433.
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