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学科主题: 临床医学
题名:
The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats
作者: Xu, Fei1,2; Zhang, Bingxi2; Li, Tianzuo2
关键词: local anesthetics ; neurotoxicity ; post partum ; spinal anesthesia
刊名: FUNDAMENTAL & CLINICAL PHARMACOLOGY
发表日期: 2013-08-01
DOI: 10.1111/j.1472-8206.2012.01034.x
卷: 27, 期:4, 页:427-433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: INDUCED CONDUCTION BLOCKADE ; RABBIT VAGUS NERVE ; SYSTEMIC TOXICITY ; PREGNANT EWES ; IN-VITRO ; BUPIVACAINE ; LEVOBUPIVACAINE ; ROPIVACAINE ; INCREASES ; INFUSION
英文摘要:

During the perinatal period, the pharmacokinetics and pharmacodynamics of drugs may be altered. Data about the neurotoxicity of intrathecal local anesthetics in the peripartum period are lacking. So we hypothesized that the neurotoxicity of intrathecal lidocaine during perinatal period may be changed. Therefore, we designed the present study to determine whether the neurotoxicity of intrathecal lidocaine in postpartum rats would be different from that in nonpregnant, virgin rats. Postpartum and nonpregnant rats randomly received an intrathecal infusion of lidocaine 50mg/mL in saline, lidocaine 20mg/mL in saline, or saline for 1h at a rate of 1L/min. Four days after drug infusion, the rats were assessed for persistent impairment of sensory and motor function (MF) using the tail-flick (TF) test, paw pressure test, and MF score. Spinal cords and nerve roots were obtained for light and electron microscopic examinations, and the injury scores were compared between groups. The TF latencies and the mean nerve injury scores of the postpartum group were significantly higher than those of nonpregnant group. Lidocaine induced a dose-dependent impairment in TF latencies and nerve injury scores. There was no significant interaction between postpartum and the drug. Our results suggest that the neurotoxicity of intrathecal lidocaine is enhanced in rats during the early postpartum period compared with nonpregnant, virgin rats.

语种: 英语
WOS记录号: WOS:000320775400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64839
Appears in Collections:北京大学第三临床医学院_麻醉科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Affiliated Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China

Recommended Citation:
Xu, Fei,Zhang, Bingxi,Li, Tianzuo. The neurotoxicity of intrathecal lidocaine is enhanced in postpartum compared to virgin rats[J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY,2013,27(4):427-433.
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