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学科主题: 临床医学
题名:
Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer
作者: Guo, Jianping; Shou, Chengchao; Meng, Lin; Jiang, Beihai; Bin Dong; Yao, Lihua; Xie, Yuntao; Zhang, Jianzhi; Chen, Yiding; Budman, Daniel R.; Shi, Yuenian Eric
关键词: synuclein gamma ; breast cancer ; prognosis ; chaperone protein
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2007-09-15
DOI: 10.1002/ijc.22763
卷: 121, 期:6, 页:1296-1305
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ESTROGEN-RECEPTOR ; ALPHA-SYNUCLEIN ; ABERRANT EXPRESSION ; ALZHEIMER-DISEASE ; GENE ; METASTASIS ; PROMOTES ; CELLS ; IDENTIFICATION ; STIMULATION
英文摘要:

Synuclein 7 (SNCG), previously identified as a breast cancer-specific gene (BCSG1), is highly expressed in breast carcinomas but not in normal epithelium. SNCG regulates many pathways in growth and progression of breast cancer. To determine if SNCG is a biomarker for clinical prognosis of breast cancer, we generated a panel of murine monoclonal antibodies (mAbs) against human SNCG and correlated SNCG protein expression in 358 clinical breast cancer specimens with clinical outcome. A panel of 14 mAbs was characterized by ELISA, immunoprecipitation (IP), Western blot, immunocytochemistry and immunohistochemistry. SNCG protein expression was determined in 438 clinical breast specimens by immunohistochemical analysis using mAb 5C5. Expression of SNCG was strongly correlated with the stage, lymph node involvement, metastasis, tumor size and Her-2 status, but its expression was not associated with ER and PR expression status. While 71.4% of advanced breast cancers were positive for SNCG expression, only 26.8% of Stage I/II breast cancers were positive for SNCG expression and 5.2% of benign hyperplasia expressed SNCG. SNCG protein was not detectable in normal tissue adjacent to breast cancer. After a median follow-up of 64 months, patients with an SNCG-positive tumor had a significfintly shorter disease-free survival and overall survival and a high probability of death compared no expression of SNCG. Multivariate analysis demonstrated that SNCG was a strong independent prognostic variable. SNCG is a new unfavorable prognostic marker for breast cancer progression and a potential target for breast cancer treatment. (c) 2007 Wiley-Liss, Inc.

语种: 英语
WOS记录号: WOS:000248976800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64843
Appears in Collections:北京大学临床肿瘤学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc hosp & inst, Dept Radiat Oncol, Beijing 100871, Peoples R China
2.Albert Einstein Coll Med, N Shore Long Island Jewish Hlth Syst, Feinstein Inst Med Res, Bronx, NY 10467 USA

Recommended Citation:
Guo, Jianping,Shou, Chengchao,Meng, Lin,et al. Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer[J]. INTERNATIONAL JOURNAL OF CANCER,2007,121(6):1296-1305.
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