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Modelling the potential impact of population-wide and targeted high-risk blood pressure-lowering strategies on cardiovascular disease in China
Qin, Xueying1; Jackson, Rod2; Marshall, Roger2; Lee, Liming1; Cao, Weihua1; Zhan, Siyan1; Hu, Yonghua1
关键词cardiovascular diseases hypertension population-wide strategy targeted strategy
刊名EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
2009-02-01
DOI10.1097/HJR.0b013e32831fd6de
16期:1页:96-101
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-HEART-DISEASE ; PRIMARY PREVENTION ; REDUCTION
英文摘要

Background To estimate the impact of population-wide and high-risk blood pressure-lowering strategies on cardiovascular disease (CVD) incidence in China.

Design A modelling study based on a community cohort of 30 362 men and women aged 35-74 years in urban Shanghai, China, 3.3% of whom have existing CVD.

Methods We modelled three blood pressure-lowering strategies: population-wide salt reduction, or anti hypertensive drug treatment (following Chinese guidelines) for two subpopulations with either high blood pressure (>= 150/95 mmHg), or high baseline-predicted CVD risk ( >= 10% in 10 years based on a multivariate risk model). Avoidable CVD events were estimated by applying a range of relative risk reductions in CVD, 5-7.5% for population-wide salt reduction and 20-25% for drug treatment derived from meta-analyses. Drug compliance was assumed to be 50%.

Results Population-wide salt reduction would avoid 240-362 events per 100 000 population over 10 years. Drug treatment for the 14.1 % of people with raised blood pressure could avoid 217-273 events, whereas treating the 14.2% of people with predicted 10-year CVD risk over 10% would avoid 310-385 events. Of the prevented events, 70-80% would occur in over 60 years and almost a third of the events were predicted to occur among the 3.3% of people with prevalent CVD.

Conclusion Population-wide and high-risk blood pressure-lowering strategies would have a similar impact on CVD incidence in urban China. The expected epidemic of CVD could be reduced by highly targeted drug treatment while more sustainable population-wide strategies are put in place. Eur J Cardiovasc Prev Rehabil 16:96-101 (C) 2009 The European Society of Cardiology

语种英语
WOS记录号WOS:000264365000016
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64845
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
2.Univ Auckland, Epidemiol & Biostat Sect, Sch Populat Hlth, Auckland 1, New Zealand
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GB/T 7714
Qin, Xueying,Jackson, Rod,Marshall, Roger,et al. Modelling the potential impact of population-wide and targeted high-risk blood pressure-lowering strategies on cardiovascular disease in China[J]. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION,2009,16(1):96-101.
APA Qin, Xueying.,Jackson, Rod.,Marshall, Roger.,Lee, Liming.,Cao, Weihua.,...&Hu, Yonghua.(2009).Modelling the potential impact of population-wide and targeted high-risk blood pressure-lowering strategies on cardiovascular disease in China.EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION,16(1),96-101.
MLA Qin, Xueying,et al."Modelling the potential impact of population-wide and targeted high-risk blood pressure-lowering strategies on cardiovascular disease in China".EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION 16.1(2009):96-101.
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