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学科主题: 临床医学
题名:
Prevalence and Associated Factors of Diabetes and Impaired Fasting Glucose in Chinese Hypertensive Adults Aged 45 to 75 Years
作者: Qin, Xianhui1; Li, Jianping2; Zhang, Yan2; Ma, Wei2; Fan, Fangfang2; Wang, Binyan1; Xing, Houxun3; Tang, Genfu4; Wang, Xiaobin5; Xu, Xin6; Xu, Xiping6; Huo, Yong2
刊名: PLOS ONE
发表日期: 2012-08-03
DOI: 10.1371/journal.pone.0042538
卷: 7, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RISK-FACTORS ; METABOLIC SYNDROME ; POPULATION ; DISEASE ; METAANALYSIS ; MELLITUS ; WOMEN ; C677T ; MEN ; POLYMORPHISMS
英文摘要:

Objective: This study examined the prevalence of impaired fasting glucose (IFG) and diabetes and their associated factors in 17,184 Chinese hypertensive adults aged 45-75 years.

Methods: A cross-sectional investigation was carried out in a rural area of Lianyungang, China. Previously undiagnosed diabetes [fasting plasma glucose (FPG) >= 7.0mmol/l] and IFG (6.1-6.9mmol/l) were defined based on FPG concentration. Previously diagnosed diabetes was determined on the basis of self-report. Total diabetes included both previously diagnosed diabetes and previously undiagnosed diabetes.

Results: The prevalence of previously diagnosed diabetes, undiagnosed diabetes, and IFG were 3.4%, 9.8%, and 14.1%, respectively. About 74.2% of the participants with diabetes had not previously been diagnosed. In the multivariable logistic-regression model, older age, men, antihypertensive treatment, obesity (BMI >= 25kg/m(2)), abdominal obesity (waist circumference >= 90cm for men and >= 80cm for women), non-current smoking, a family history of diabetes, higher heart rate, lower physical activity levels, and inland residence (versus coastal) were significantly associated with both total diabetes and previously undiagnosed diabetes. Furthermore, methylene-tetrahydrofolate reductase (MTHFR) 677 TT genotype was an independent associated factor for total diabetes, and current alcohol drinking was an independent associated factor for previously undiagnosed diabetes. At the same time, older age, men, abdominal obesity, non-current smoking, current alcohol drinking, a family history of diabetes, higher heart rate, and inland residence (versus coastal) were important independent associated factors for IFG.

Conclusion: In conclusion, we found a high prevalence of diabetes in Chinese hypertensive adults. Furthermore, about three out of every four diabetic adults were undiagnosed. Our results suggest that population-level measures aimed at the prevention, identification (even if only based on the FPG evaluation), and treatment of diabetes should be urgently taken to overcome the diabetes epidemic in Chinese hypertensive adults.

语种: 英语
所属项目编号: 2012zx09101-105 ; 2012CB517703 ; (2010)1744
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China ; Major State Basic Research Development Program of China (973 program) ; Department of Development and Reform, Shenzhen ; Department of Science, Industry, Trade and Information Technology, Shenzhen
WOS记录号: WOS:000307284100124
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64847
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Lianyungang Ctr Adv Res Cardiovasc Dis, Lianyungang, Peoples R China
3.Anhui Med Univ, Sch Hlth Adm, Hefei, Peoples R China
4.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
5.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Early Life Origins Dis, Dept Populat Family & Reprod Hlth, Baltimore, MD USA
6.So Med Univ, Inst Nephrol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Qin, Xianhui,Li, Jianping,Zhang, Yan,et al. Prevalence and Associated Factors of Diabetes and Impaired Fasting Glucose in Chinese Hypertensive Adults Aged 45 to 75 Years[J]. PLOS ONE,2012,7(8).
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