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学科主题: 临床医学
题名:
Comparison of Recovery Patterns and Prognostic Indicators for Ischemic and Hemorrhagic Stroke in China The ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) Registry Study
作者: Wei, Jade W.1; Heeley, Emma L.1; Wang, Ji-Guang3; Huang, Yining4; Wong, Lawrence K. S.5; Li, Zhengyi6; Heritier, Stephane1; Arima, Hisatomi1; Anderson, Craig S.1; ChinaQUEST Investigators
关键词: China ; outcome ; stroke
刊名: STROKE
发表日期: 2010-09-01
DOI: 10.1161/STROKEAHA.110.586909
卷: 41, 期:9, 页:1877-1883
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]: Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]: BLOOD-PRESSURE ; INTRACEREBRAL HEMORRHAGE ; INPATIENT REHABILITATION ; 1ST-EVER STROKE ; INNER-MONGOLIA ; RISK-FACTORS ; MORTALITY ; MULTICENTER ; DISCHARGE ; SURVIVAL
英文摘要:

Background and Purpose-Limited data exist on the comparative recovery patterns and outcomes of patients with ischemic stroke and intracerebral hemorrhage in China.

Methods-Data on baseline characteristics and outcomes of 6354 patients at 3 and 12 months poststroke are from ChinaQUEST (QUality Evaluation of Stroke Care and Treatment), a multicenter, prospective, 62-hospital registry study in China. Logistic regression was used to determine factors associated with a poor outcome defined by death/dependency (modified Rankin Scale score of 3 to 5) on follow-up. Generalized estimating equations were used to assess variations in recovery pattern by stroke type.

Results-Baseline severity and rate of functional recovery in the early phase were significantly greater for intracerebral hemorrhage. However, patients with ischemic stroke were on average twice as likely to experience a good outcome (modified Rankin Scale score <3) by 12 months poststroke (OR: 1.98, CI: 1.76 to 2.24). In patients with ischemic stroke, diabetes and atrial fibrillation were strongly associated with a poor outcome at 12 months poststroke even after adjustment for confounding factors such as age, prior stroke/dependency, time to presentation, and stroke severity, whereas use of antiplatelets and lipid-lowering therapy after stroke were associated with improved outcome. For patients with intracerebral hemorrhage, low education and atrial fibrillation were associated with a poor outcome after adjustment for potential confounders and antihypertensive use was strongly associated with improved outcome.

Conclusions-Patients with intracerebral hemorrhage and ischemic stroke have different recovery patterns in China. However, they share similar prognostic factors and in the use of evidence-based secondary prevention therapies to maximize chances of a good outcome. (Stroke. 2010; 41:1877-1883.)

语种: 英语
项目资助者: Macquarie Bank Foundation ; George Foundation ; AstraZeneca Pharmaceutical China
WOS记录号: WOS:000281503000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64848
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Univ Sydney, Sydney, NSW 2006, Australia
2.Xian Traff Univ, Coll Med, Hosp 1, Xian, Peoples R China
3.Royal Prince Alfred Hosp, George Inst Int Hlth, Camperdown, NSW 2050, Australia
4.Shanghai Jiao Tong Univ, Ruijin Hosp, Ctr Epidemiol Studies & Clin Trials, Sch Med, Shanghai 200030, Peoples R China
5.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
6.Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wei, Jade W.,Heeley, Emma L.,Wang, Ji-Guang,et al. Comparison of Recovery Patterns and Prognostic Indicators for Ischemic and Hemorrhagic Stroke in China The ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) Registry Study[J]. STROKE,2010,41(9):1877-1883.
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