IR@PKUHSC  > 北京大学第一临床医学院  > 感染疾病科
学科主题临床医学
Case-Control Study on Prednisolone Combined With Ursodeoxycholic Acid and Azathioprine in Pure Primary Biliary Cirrhosis With High Levels of Immunoglobulin G and Transaminases Efficacy and Safety Analysis
Fang, Yu-Qing1,2; Lv, Dong-Xia3; Jia, Wei1,2; Li, Jun1,2; Deng, Yong-Qiong1,2; Wang, Yan1,2; Yu, Min1,2; Wang, Gui-Qiang1,2
刊名MEDICINE
2014-10-01
DOI10.1097/MD.0000000000000104
93期:20
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]RANDOMIZED CONTROLLED-TRIALS ; BIOCHEMICAL RESPONSE ; DOUBLE-BLIND ; THERAPY ; BUDESONIDE ; FIBROSIS ; PLACEBO ; PREDICT ; INDEX
英文摘要

To the best of our knowledge, this is the first study to address the use of glucocorticoids in the comparatively special population of pure primary biliary cirrhosis (PBC) patients who have high levels of immunoglobulin G (IgG) and transaminases but do not have PBC-autoimmune hepatitis overlap syndrome. Ursodeoxycholic acid (UDCA) is now assumed to be the standard therapy for PBC patients. However, patients treated with UDCA still have a risk of progression to cirrhosis and end-stage liver disease. The most recent European Association for the Study of the Liver guidelines of 2009 declared that further studies on glucocorticoid therapy in this disease should be a priority. Therefore, we designed this 3-year longitudinal retrospective study, which might provide deep insight into the treatment for PBC.

The aim of this study was to assess whether the combination of prednisolone, UDCA, and azathioprine was superior to UDCA alone in these PBC patients.

Sixty patients were enrolled in this study. Thirty-one patients underwent UDCA monotherapy, and 29 patients were treated with prednisolone, UDCA, and azathioprine. We analyzed their biochemistries, immune parameters, liver synthetic function, and noninvasive assessments of liver fibrosis, as well as treatment efficacy and adverse effects at baseline and at 1, 3, 6, 12, 24, and 36 months.

Alkaline phosphatase (ALP), gamma-glutamyl transpeptidase, alanine aminotransferase, and aspartate aminotransferase levels and the aspartate aminotransferase-to-platelet ratio index (APRI) and S-index improved dramatically in both groups, whereas IgG levels only decreased in the combination group (all P<0.05). Albumin (ALB) levels decreased in the UDCA group but increased with the combination treatment at 36 months. Significant differences between the 2 groups were observed at 36 months in ALP (P = 0.005), IgG (P = 0.002), ALB (P = 0.002), APRI (P = 0.015), and S-index (P = 0.020). Prednisolone combined with UDCA and azathioprine showed a higher efficacy based on our new criteria.

The combination of prednisolone, UDCA, and azathioprine is superior to UDCA alone for the treatment of pure PBC patients with high levels of IgG and transaminases. Side effects were minimal or absent.

语种英语
WOS记录号WOS:000344146400005
资助机构key disciplines of Beijing ; key clinical medical disciplines of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64851
专题北京大学第一临床医学院_感染疾病科
作者单位1.Peking Univ, Hosp 1, Ctr Liver Dis, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China
3.Sixth Hosp Shenyang, Dept Infect Dis, Shenyang, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
Fang, Yu-Qing,Lv, Dong-Xia,Jia, Wei,et al. Case-Control Study on Prednisolone Combined With Ursodeoxycholic Acid and Azathioprine in Pure Primary Biliary Cirrhosis With High Levels of Immunoglobulin G and Transaminases Efficacy and Safety Analysis[J]. MEDICINE,2014,93(20).
APA Fang, Yu-Qing.,Lv, Dong-Xia.,Jia, Wei.,Li, Jun.,Deng, Yong-Qiong.,...&Wang, Gui-Qiang.(2014).Case-Control Study on Prednisolone Combined With Ursodeoxycholic Acid and Azathioprine in Pure Primary Biliary Cirrhosis With High Levels of Immunoglobulin G and Transaminases Efficacy and Safety Analysis.MEDICINE,93(20).
MLA Fang, Yu-Qing,et al."Case-Control Study on Prednisolone Combined With Ursodeoxycholic Acid and Azathioprine in Pure Primary Biliary Cirrhosis With High Levels of Immunoglobulin G and Transaminases Efficacy and Safety Analysis".MEDICINE 93.20(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fang, Yu-Qing]的文章
[Lv, Dong-Xia]的文章
[Jia, Wei]的文章
百度学术
百度学术中相似的文章
[Fang, Yu-Qing]的文章
[Lv, Dong-Xia]的文章
[Jia, Wei]的文章
必应学术
必应学术中相似的文章
[Fang, Yu-Qing]的文章
[Lv, Dong-Xia]的文章
[Jia, Wei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。