IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Lower Treatment Blood Pressure Is Associated With Greatest Reduction in Hematoma Growth After Acute Intracerebral Hemorrhage
Arima, Hisatomi1,2; Anderson, Craig S.1,2; Wang, Ji Guang3; Huang, Yining4; Heeley, Emma1,2; Neal, Bruce1,2; Woodward, Mark1,2; Skulina, Christian1,2; Parsons, Mark W.5,6; Ping, Bin7; Tao, Qing Ling8; Li, Yue Chun9; Jiang, Jian Dong10; Tai, Li Wen11; Zhang, Jin Li12; Xu, En13; Cheng, Yan14; Morgenstern, Lewis B.15; Chalmers, John1,2; Intensive Blood Pressure Reduction
关键词stroke intracerebral hemorrhage hypertension blood pressure lowering clinical trial
刊名HYPERTENSION
2010-11-01
DOI10.1161/HYPERTENSIONAHA.110.154328
56期:5页:852-858
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者National Health and Medical Research Council of Australia ; University of Sydney ; Astra Zeneca ; Boehringer Ingelheim ; Novo Nordisk ; Sanofi-Aventis ; Servier ; Novartis ; Omron ; Pfizer ; Roche ; Takeda ; Amgen ; GlaxoSmithKline ; Tanabe ; Johnson and Johnson ; Merck Schering Plough ; United Healthcare Group ; National Health and Medical Research Council of Australia ; University of Sydney ; Astra Zeneca ; Boehringer Ingelheim ; Novo Nordisk ; Sanofi-Aventis ; Servier ; Novartis ; Omron ; Pfizer ; Roche ; Takeda ; Amgen ; GlaxoSmithKline ; Tanabe ; Johnson and Johnson ; Merck Schering Plough ; United Healthcare Group
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]PERIHEMATOMAL EDEMA ; STROKE COUNCIL ; TRIAL ; MANAGEMENT ; MORTALITY ; INTERACT ; ENLARGEMENT ; GUIDELINES ; CARE
英文摘要

The pilot phase of the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT) showed that rapid blood pressure (BP) lowering can attenuate hematoma growth in acute intracerebral hemorrhage. We sought to define the systolic BP level associated with greatest attenuation of hematoma growth. INTERACT included 404 patients with computed tomographic-confirmed intracerebral hemorrhage, elevated systolic BP (150 to 220 mm Hg), and capacity to commence BP lowering treatment within 6 hours of onset. Computed tomography was done at baseline and at 24 hours using standardized techniques, with digital images analyzed centrally, blinded to clinical data. Associations of baseline and achieved on-treatment (mean during the first 24 hours) systolic BP levels with the primary outcome of increase in hematoma volume were explored. There were 346 patients with duplicate computed tomographic scans. There was no significant association between baseline systolic BP levels and either the absolute or proportional growth in hematoma volume (P trend=0.26 and 0.12, respectively). By contrast, achieved on-treatment systolic BP levels in the first 24 hours were clearly associated with both absolute and proportional hematoma growth (both P trend=0.03). Maximum reduction in hematoma growth occurred in the one third of participants with the lowest on-treatment systolic BP levels (median: 135 mm Hg). Intensive BP reduction to systolic levels between 130 and 140 mm Hg is likely to provide the maximum protection against hematoma growth after intracerebral hemorrhage. (Hypertension. 2010;56:852-858.)

语种英语
所属项目编号358395
资助者National Health and Medical Research Council of Australia ; University of Sydney ; Astra Zeneca ; Boehringer Ingelheim ; Novo Nordisk ; Sanofi-Aventis ; Servier ; Novartis ; Omron ; Pfizer ; Roche ; Takeda ; Amgen ; GlaxoSmithKline ; Tanabe ; Johnson and Johnson ; Merck Schering Plough ; United Healthcare Group ; National Health and Medical Research Council of Australia ; University of Sydney ; Astra Zeneca ; Boehringer Ingelheim ; Novo Nordisk ; Sanofi-Aventis ; Servier ; Novartis ; Omron ; Pfizer ; Roche ; Takeda ; Amgen ; GlaxoSmithKline ; Tanabe ; Johnson and Johnson ; Merck Schering Plough ; United Healthcare Group
WOS记录号WOS:000283240400537
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64853
专题北京大学第一临床医学院
作者单位1.Univ Newcastle, Hunter Med Res Inst, New Lambton, Australia
2.Royal Prince Alfred Hosp, George Inst Global Hlth, Sydney, NSW, Australia
3.Univ Sydney, Sydney, NSW 2006, Australia
4.Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Ctr Epidemiol Studies & Clin Trials, Shanghai 200030, Peoples R China
5.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
6.Univ Newcastle, John Hunter Hosp, New Lambton, Australia
7.Beijing Union Med Coll Hosp, Beijing, Peoples R China
8.Cent Hosp, Shanghai, Peoples R China
9.Baotou Cent Hosp, Baotou, Peoples R China
10.Second People Hosp Lianyungang, Lianyungang, Peoples R China
11.Hebei Med Univ, Hosp 2, Shijiazhuang, Peoples R China
12.Chinese PLA 263 Hosp, Beijing, Peoples R China
13.Guangzhou Med Coll, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
14.Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China
15.Univ Michigan, Med Ctr, Ann Arbor, MI USA
推荐引用方式
GB/T 7714
Arima, Hisatomi,Anderson, Craig S.,Wang, Ji Guang,et al. Lower Treatment Blood Pressure Is Associated With Greatest Reduction in Hematoma Growth After Acute Intracerebral Hemorrhage[J]. HYPERTENSION,2010,56(5):852-858.
APA Arima, Hisatomi.,Anderson, Craig S..,Wang, Ji Guang.,Huang, Yining.,Heeley, Emma.,...&Intensive Blood Pressure Reduction.(2010).Lower Treatment Blood Pressure Is Associated With Greatest Reduction in Hematoma Growth After Acute Intracerebral Hemorrhage.HYPERTENSION,56(5),852-858.
MLA Arima, Hisatomi,et al."Lower Treatment Blood Pressure Is Associated With Greatest Reduction in Hematoma Growth After Acute Intracerebral Hemorrhage".HYPERTENSION 56.5(2010):852-858.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Arima, Hisatomi]的文章
[Anderson, Craig S.]的文章
[Wang, Ji Guang]的文章
百度学术
百度学术中相似的文章
[Arima, Hisatomi]的文章
[Anderson, Craig S.]的文章
[Wang, Ji Guang]的文章
必应学术
必应学术中相似的文章
[Arima, Hisatomi]的文章
[Anderson, Craig S.]的文章
[Wang, Ji Guang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。