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Lack of evidence for association between the serotonin transporter gene (SLC6A4) polymorphisms and autism in the Chinese trios
Wu, SP; Guo, YQ; Jia, MX; Ruan, Y; Shuang, M; Liu, J; Gong, XH; Zhang, YB; Yang, JZ; Yang, XL; Zhang, D
关键词autism serotonin transporter gene (SLC6A4) single nucleotide polymorphism (SNP) the transmission disequilibrium test (TDT) haplotype analysis
刊名NEUROSCIENCE LETTERS
2005-06-10
DOI10.1016/j.neulet.2005.01.073
381期:1-2页:1-5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]WHOLE-BLOOD SEROTONIN ; OBSESSIVE-COMPULSIVE DISORDER ; LINKAGE DISEQUILIBRIUM ; GENOMEWIDE SCREEN ; TRANSMISSION ; VARIANTS ; FAMILIES ; REGION ; RELATIVES ; CHILDREN
英文摘要

Serotonin regulates several aspects of brain development, and it is involved in a range of behaviors frequently disturbed in autistic disorder. The serotonin transporter is a critical component of the serotonergic system. The serotonin transporter gene (SLC6A4) is of special interest given the nature of the biological findings and the reported effects of selective serotonin reuptake inhibitors of autistic Symptoms. So far the genetics researches of the SLC6A4 gene have given conflicting results. The aim of study was to investigate the association between the SLC6A4 gene and autism in the Chinese Han population. The present study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the SLC6A4 gene by using the polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) analysis. We performed a family-based association study of these polymorphisms in 175 Chinese Han family trios. Linkage disequilibrium (LD) measurement (D ′) analysis showed the presence of LD between markers across the locus. No significant evidence of association was found at any of the markers detected by using the transmission disequilibrium test (TDT) and haplotype analyses in all samples and male samples. Our findings suggest that it is unlikely that DNA variations in the SLC6A4 gene play a significant role in the genetic predisposition to autism in the Chinese Han population or that allelic heterogeneity at the SLC6A4 loci dilutes potential disease-allele association. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000229390400001
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64854
专题北京大学精神卫生研究所
作者单位Peking Univ, Inst Mental Hlth, Dept Biochem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wu, SP,Guo, YQ,Jia, MX,et al. Lack of evidence for association between the serotonin transporter gene (SLC6A4) polymorphisms and autism in the Chinese trios[J]. NEUROSCIENCE LETTERS,2005,381(1-2):1-5.
APA Wu, SP.,Guo, YQ.,Jia, MX.,Ruan, Y.,Shuang, M.,...&Zhang, D.(2005).Lack of evidence for association between the serotonin transporter gene (SLC6A4) polymorphisms and autism in the Chinese trios.NEUROSCIENCE LETTERS,381(1-2),1-5.
MLA Wu, SP,et al."Lack of evidence for association between the serotonin transporter gene (SLC6A4) polymorphisms and autism in the Chinese trios".NEUROSCIENCE LETTERS 381.1-2(2005):1-5.
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