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Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes
Zhao, Ming; Zhang, Zhao-Feng; Ding, Ye; Wang, Jun-Bo; Li, Yong
关键词insulin resistance NF-kappa B PTP1B Astragalus polysaccharide
刊名MOLECULES
2012-06-01
DOI10.3390/molecules17067083
17期:6页:7083-7092
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Chemistry
关键词[WOS]METABOLIC SYNDROME ; CELLS ; OVEREXPRESSION ; INFLAMMATION ; REVERSAL
英文摘要

We investigated the effects of Astragalus polysaccharide (APS) on palmitate-induced insulin resistance in C2C12 skeletal muscle myotubes. Palmitate-reduced glucose uptake was restored by APS. APS prevented palmitate-induced C2C12 myotubes from impaired insulin signaling by inhibiting Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1) and increasing Ser473 phosphorylation of Akt. Moreover, the increases in protein-tyrosine phosphatase-1B (PTP1B) protein level and NF-kappa B activation associated with palmitate treatment were also prevented by APS. However the treatment with APS didn′t change AMP-activated protein kinase (AMPK) activation in palmitate-induced myotubes. The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappa B but not AMPK pathway.

语种英语
所属项目编号2006BAD27B01
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000305800400062
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64856
专题北京大学公共卫生学院
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Ming,Zhang, Zhao-Feng,Ding, Ye,et al. Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes[J]. MOLECULES,2012,17(6):7083-7092.
APA Zhao, Ming,Zhang, Zhao-Feng,Ding, Ye,Wang, Jun-Bo,&Li, Yong.(2012).Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes.MOLECULES,17(6),7083-7092.
MLA Zhao, Ming,et al."Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes".MOLECULES 17.6(2012):7083-7092.
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