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学科主题: 公共卫生
题名:
Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes
作者: Zhao, Ming; Zhang, Zhao-Feng; Ding, Ye; Wang, Jun-Bo; Li, Yong
关键词: insulin resistance ; NF-kappa B ; PTP1B ; Astragalus polysaccharide
刊名: MOLECULES
发表日期: 2012-06-01
DOI: 10.3390/molecules17067083
卷: 17, 期:6, 页:7083-7092
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: METABOLIC SYNDROME ; CELLS ; OVEREXPRESSION ; INFLAMMATION ; REVERSAL
英文摘要:

We investigated the effects of Astragalus polysaccharide (APS) on palmitate-induced insulin resistance in C2C12 skeletal muscle myotubes. Palmitate-reduced glucose uptake was restored by APS. APS prevented palmitate-induced C2C12 myotubes from impaired insulin signaling by inhibiting Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1) and increasing Ser473 phosphorylation of Akt. Moreover, the increases in protein-tyrosine phosphatase-1B (PTP1B) protein level and NF-kappa B activation associated with palmitate treatment were also prevented by APS. However the treatment with APS didn′t change AMP-activated protein kinase (AMPK) activation in palmitate-induced myotubes. The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappa B but not AMPK pathway.

语种: 英语
所属项目编号: 2006BAD27B01
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000305800400062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64856
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Ming,Zhang, Zhao-Feng,Ding, Ye,et al. Astragalus Polysaccharide Improves Palmitate-Induced Insulin Resistance by Inhibiting PTP1B and NF-kappa B in C2C12 Myotubes[J]. MOLECULES,2012,17(6):7083-7092.
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