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学科主题: 基础医学
题名:
Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia
作者: Zhou, Ye1,2,3,4; Li, Hui Li1,2,3,4; Zhao, Rui1,2,3,4; Yang, Li Tao1,2,3,4; Dong, Yan1,2,3,4; Yue, Xin1,2,3,4; Ma, Yao Ying1,2,3,4; Wang, Zhuo1,2,3,4; Chen, Jianguo5,6,7; Cui, Cai Lian1,2,3,4; Yu, Albert Cheung-Hoi1,2,3,4,8,9
关键词: NOS1 ; MK-801 ; NR1 ; NR2
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2010-12-01
DOI: 10.1007/s11064-010-0325-x
卷: 35, 期:12, 页:2124-2134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; CEREBELLAR GRANULE NEURONS ; RAT HIPPOCAMPAL SLICES ; ER RETENTION SIGNAL ; NMDA RECEPTOR ; PRIMARY CULTURES ; IN-VITRO ; CORTICAL ASTROCYTES ; POSTNATAL-DEVELOPMENT ; GLUTAMATE RECEPTORS
英文摘要:

The expression of the N-methyl-D-aspartate receptor (NMDA-R) in astrocytes is controversial. The receptor is commonly considered neuron-specific. We showed that astrocytes in primary cultures differentially expressed mRNA of NMDA-R subunits, NR1, NR2A and NR2B, in development, ischemia and post-ischemia. One-week-old cultures expressed detectable NR1 mRNA, which fell significantly at 2 weeks and became barely detectable at 4 weeks. NR2A and NR2B mRNA were both significantly up-regulated from 1 to 2 weeks. In 4 weeks, 2 h of ischemia caused a significant up-regulation of NR1 and NR2B mRNA; while 6 h caused down-regulation of NR2A mRNA. Under 3 h of post-ischemia, only NR1 mRNA was increased. Ischemia induced the expression of major NMDA-R effecter, nitric oxide synthase 1, which was unaffected by AMPA-R antagonist CNQX, but dose-dependently inhibited by NMDA-R specific antagonist MK-801. These findings reflected that astrocyte could express inducible functional NMDA receptors without the presence of neurons.

语种: 英语
所属项目编号: 30270426 ; 30470543 ; 30670644 ; 30870818 ; 31070974 ; 7032026 ; 7051004 ; 7091004 ; 2006AA02Z452 ; 2011CB504400
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National High Technology Research and Development Program of China (863 Program) ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000285364900029
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64857
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
3.Peking Univ, Ctr Infect Dis, Beijing 100191, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
5.Peking Univ, Minist Publ Hlth, Key Lab Neurosci, Beijing 100191, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Beijing 100191, Peoples R China
7.Peking Univ, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China
8.Peking Univ, State Key Lab Biomembrane & Membrane Bioengn, Beijing 100871, Peoples R China
9.Peking Univ, Inst Syst Biomed, Lab Translat Med, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Ye,Li, Hui Li,Zhao, Rui,et al. Astrocytes Express N-Methyl-D-Aspartate Receptor Subunits in Development, Ischemia and Post-Ischemia[J]. NEUROCHEMICAL RESEARCH,2010,35(12):2124-2134.
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