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学科主题: 药学
题名:
Cyclic Adenosine 5 ′-Diphosphoribose (cADPR) Mimics Used as Molecular Probes in Cell Signaling
作者: Zhang, Liangren1; Yue, Jianbo2; Zhang, Li-He1
关键词: calcium ; cell cycle ; nucleotides ; signal transduction ; structure-activity relationships
刊名: CHEMICAL RECORD
发表日期: 2015-04-01
DOI: 10.1002/tcr.201402072
卷: 15, 期:2, 页:511-523
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: TYPE-3 RYANODINE RECEPTOR ; CALCIUM-RELEASE ACTIVITY ; ADP-RIBOSE ANTAGONIST ; MEMBRANE-PERMEANT ; CA2+ RELEASE ; T-LYMPHOCYTES ; CARBOCYCLIC-RIBOSE ; ANALOGS ; DERIVATIVES ; AGONIST
英文摘要:

Cyclic adenosine 5-diphosphate ribose (cADPR) is a second messenger in the Ca2+ signaling pathway. To elucidate its molecular mechanism in calcium release, a series of cADPR analogues with modification on ribose, nucleobase, and pyrophosphate have been investigated. Among them, the analogue with the modification of the northern ribose by ether linkage substitution (cIDPRE) exhibits membrane-permeate Ca2+ agonistic activity in intact HeLa cells, human T cells, mouse cardiac myocytes and neurosecretory PC12 cell lines; thus, cIDPRE and coumarin-caged cIDPRE are valuable probes to investigate the cADPR-mediated Ca2+ signal pathway.

语种: 英语
所属项目编号: 91213302 ; 81172917
项目资助者: National Natural Sciences Foundation of China ; Research Grant Council (RGC)
WOS记录号: WOS:000353919100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64858
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.City Univ Hong Kong, Dept Biomed Sci, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhang, Liangren,Yue, Jianbo,Zhang, Li-He. Cyclic Adenosine 5 ′-Diphosphoribose (cADPR) Mimics Used as Molecular Probes in Cell Signaling[J]. CHEMICAL RECORD,2015,15(2):511-523.
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