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Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines
Han, DM; Wang, C; Zhao, M; Peng, SQ
刊名PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
2000
30期:3页:231-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]MELATONIN
英文摘要

5-Methoxytryptamine and L-tryptophan methyl ester were acylated with malonic acid, dimethyl malonate, or succinic anhydride to produce the corresponding N, N′-dicarbonyl-tryptamine derivatives. The analgesic activity was evaluated by the tail flick test. All of the compounds exhibited desirable analgesic potency. This result is consistent with that of N-(N-acetyl-L-tryptophanyl)-5-methoxytryptamine and confirmed that introducing substituted tryptamine into the amide chain of melatonin does enhance analgesic potency.

语种英语
WOS记录号WOS:000088278900004
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64883
专题北京大学药学院
作者单位Beijing Med Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Han, DM,Wang, C,Zhao, M,et al. Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines[J]. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,2000,30(3):231-240.
APA Han, DM,Wang, C,Zhao, M,&Peng, SQ.(2000).Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines.PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,30(3),231-240.
MLA Han, DM,et al."Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines".PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY 30.3(2000):231-240.
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