| 学科主题 | 药学 |
| Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines | |
| Han, DM; Wang, C; Zhao, M; Peng, SQ | |
| 刊名 | PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
 |
| 2000 | |
| 卷 | 30期:3页:231-240 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology |
| 关键词[WOS] | MELATONIN |
| 英文摘要 | 5-Methoxytryptamine and L-tryptophan methyl ester were acylated with malonic acid, dimethyl malonate, or succinic anhydride to produce the corresponding N, N′-dicarbonyl-tryptamine derivatives. The analgesic activity was evaluated by the tail flick test. All of the compounds exhibited desirable analgesic potency. This result is consistent with that of N-(N-acetyl-L-tryptophanyl)-5-methoxytryptamine and confirmed that introducing substituted tryptamine into the amide chain of melatonin does enhance analgesic potency. |
| 语种 | 英语 |
| WOS记录号 | WOS:000088278900004 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/64883 |
| Collection | 北京大学药学院 |
| 作者单位 | Beijing Med Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China |
| Recommended Citation GB/T 7714 | Han, DM,Wang, C,Zhao, M,et al. Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines[J]. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,2000,30(3):231-240. |
| APA | Han, DM,Wang, C,Zhao, M,&Peng, SQ.(2000).Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines.PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,30(3),231-240. |
| MLA | Han, DM,et al."Synthesis and analgesic activity of N,N ′-dicarbonyltryptamines".PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY 30.3(2000):231-240. |
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