北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 化学生物学系  > 期刊论文
学科主题: 药学
题名:
Effects of the rare earth ions on bone resorbing function of rabbit mature osteoclasts in vitro
作者: Zhang, JC; Xu, SJ; Wang, K; Yu, SF
关键词: rare earth ion ; osteoclast ; bone resorption
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2003-10-01
DOI: 10.1360/03wb0022
卷: 48, 期:20, 页:2170-2175
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RESORPTION ; CALCIUM ; OSTEOBLASTS ; CALCITONIN ; STRONTIUM ; BEHAVIOR ; RECEPTOR ; PROTEIN ; CATION
英文摘要:

The effects of rare earth ions on bone resorbing function of osteoclasts were studied by culturing Japanese white rabbit osteoclasts on bone slices. In order to evaluate the activity of osteoclasts, the number and surface areas of lacunae were measured by photomicrography and image analysis, and the calcium concentration in the supernatant was measured by the atomic absorption spectrometry. The lacunae morphology was observed under a scanning electron microscope. The results indicated that La3+, Sm3+ and Er3+ at the concentration of 1.00x10(-5), 1.00x10(-6) and 1.00x 10(-7) mol/L and Nd3+, Gd3+ and Dy3+ at the concentration of 1.00x 10(-5) and 1.00x10(-6) mol/L inhibited osteoclastic activity as indicated by the dose-dependent reduction in the numbers and surface areas of the lacunae (P<0.01). On the contrary, the number and surface areas of lanunae were increased and osteoclastic bone resorbing function was significantly enhanced by La3+, Sm3+ and Er3+ at the concentration of 1.00x10(-8) mol/L and Nd3+, Gd3+ and Dy3+ at the concentration of 1.00x10(-7) mol/L (P<0.01). Nd3+, Gd3+ and Dy3+ had no effect on osteoclastic bone resorption function at concentrations as low as 1.00x10(-8) mol/L (P>0.05). It is suggested that the effects of rare earth ions on osteoclastic bone resorption are bidirectional, depending on concentrations and species.

语种: 英语
WOS记录号: WOS:000186305600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64891
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
3.Hebei Univ, Dept Med Chem, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

Recommended Citation:
Zhang, JC,Xu, SJ,Wang, K,et al. Effects of the rare earth ions on bone resorbing function of rabbit mature osteoclasts in vitro[J]. CHINESE SCIENCE BULLETIN,2003,48(20):2170-2175.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, JC]'s Articles
[Xu, SJ]'s Articles
[Wang, K]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, JC]‘s Articles
[Xu, SJ]‘s Articles
[Wang, K]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace