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Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population
Liu, Wei1; Li, Weimin1; Sun, Ningling2
关键词idiopathic dilated cardiomyopathy HLA-DQA1 HLA-DQB1 polymorphism genetic susceptibility
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2004-08-01
1期:4页:311-314
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
英文摘要

Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage. This study was conducted to investigate the possible association between HLA-DQA1, -DQB1 alleles and IDC in Han population in northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping. Among 68 unrelated IDC patients, 4 probands of IDC pedigrees and 100 healthy controls, we found that the alleles of HLA-DQA1* 0501 and HLA-DQB1* 0303 conferred susceptibility to IDC while DQA1* 0201 and DQB1*0502, *0504 alleles were in negative association with IDC. The serine at position 57 (SER57) in the exon of DQB1*0502 and *0504 was confirmed in our experiment as a marker for resistance to IDC. The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC.

语种英语
WOS记录号WOS:000208923500011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64893
专题北京大学第二临床医学院_心血管内科
作者单位1.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
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GB/T 7714
Liu, Wei,Li, Weimin,Sun, Ningling. Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(4):311-314.
APA Liu, Wei,Li, Weimin,&Sun, Ningling.(2004).Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population.CELLULAR & MOLECULAR IMMUNOLOGY,1(4),311-314.
MLA Liu, Wei,et al."Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population".CELLULAR & MOLECULAR IMMUNOLOGY 1.4(2004):311-314.
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