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学科主题: 临床医学
题名:
Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population
作者: Liu, Wei1; Li, Weimin1; Sun, Ningling2
关键词: idiopathic dilated cardiomyopathy ; HLA-DQA1 ; HLA-DQB1 ; polymorphism ; genetic susceptibility
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2004-08-01
卷: 1, 期:4, 页:311-314
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要:

Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage. This study was conducted to investigate the possible association between HLA-DQA1, -DQB1 alleles and IDC in Han population in northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping. Among 68 unrelated IDC patients, 4 probands of IDC pedigrees and 100 healthy controls, we found that the alleles of HLA-DQA1* 0501 and HLA-DQB1* 0303 conferred susceptibility to IDC while DQA1* 0201 and DQB1*0502, *0504 alleles were in negative association with IDC. The serine at position 57 (SER57) in the exon of DQB1*0502 and *0504 was confirmed in our experiment as a marker for resistance to IDC. The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC.

语种: 英语
WOS记录号: WOS:000208923500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64893
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Wei,Li, Weimin,Sun, Ningling. Association of HLA-DQ with Idiopathic Dilated Cardiomyopathy in a Northern Chinese Han Population[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(4):311-314.
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