|Association of cesarean delivery with anemia in infants and children in 2 large longitudinal Chinese birth cohorts|
|Li, Hong-tian1,2; Trasande, Leonardo3,4,5,6; Zhu, Li-ping7; Ye, Rong-wei1; Zhou, Yu-bo1; Liu, Jian-meng1,2|
|关键词||anemia cesarean delivery children cohort infant|
|刊名||AMERICAN JOURNAL OF CLINICAL NUTRITION|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||IRON-DEFICIENCY ANEMIA ; RANDOMIZED-CONTROLLED-TRIAL ; PLACENTAL TRANSFUSION ; BLOOD-VOLUME ; SECTION ; PREVALENCE ; PREGNANCY ; CONSENSUS ; TRENDS ; RATES|
Background: Cesarean delivery may reduce placental-fetal transfusion and thus increase the risk of early childhood anemia compared with vaginal delivery, but this notion has not been carefully studied in longitudinal cohorts.
Objective: The aim was to assess the association of cesarean delivery with anemia in infants and children in 2 longitudinal Chinese birth cohorts from different socioeconomic settings.
Design: Cohort 1 was recruited from 5 counties in northeastern China and cohort 2 from 21 counties or cities in southeastern China. Cohort 1 involved 17,423 infants born during 2006-2009 to mothers with early pregnancy baseline hemoglobin concentrations ranging from 100 to 177 g/L, whereas cohort 2 involved 122,777 children born during 19931996 to mothers with baseline hemoglobin concentrations ranging from 60 to 190 g/L. The main outcomes were anemia at 6 and 12 mo in cohort 1 and at 58 mo in cohort 2. Multiple logistic regressions were used to estimate adjusted ORs of anemia for cesarean compared with vaginal delivery. Stratified analyses were performed by pre- and postlabor cesarean delivery and according to maternal baseline hemoglobin concentration (<= 109, 110-119, 120-129, and >= 130 g/L).
Results: Cesarean delivery was not associated with anemia at 6 mo in cohort 1 (adjusted OR: 1.05; 95% CI: 0.93, 1.19); however, cesarean delivery was associated with increased anemia at 12 mo in cohort 1 (adjusted OR: 1.19; 95% CI: 1.04, 1.37) and at 58 mo in cohort 2 (adjusted OR: 1.11; 95% CI: 1.08, 1.15). The positive associations for anemia at 12 and 58 mo were consistent across maternal hemoglobin subgroups and persisted for cesarean delivery subtypes.
Conclusion: Cesarean delivery is likely associated with anemia in children, which suggests a possible need for exploring changes in obstetric care that might prevent anemia in cesarean-delivered children.
|资助机构||National Natural Science Foundation of China|
|作者单位||1.Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, Minist Hlth,Key Lab Reprod Hlth, Beijing 100191, Peoples R China|
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
3.NYU, Robert F Wagner Grad Sch Publ Serv, Sch Med, Dept Pediat, New York, NY 10003 USA
4.NYU, Robert F Wagner Grad Sch Publ Serv, Sch Med, Dept Environm Med, New York, NY 10003 USA
5.NYU, Robert F Wagner Grad Sch Publ Serv, Sch Med, Dept Populat Hlth, New York, NY 10003 USA
6.NYU, Steinhardt Sch Culture Educ & Human Dev, New York, NY 10003 USA
7.Tongji Univ, Shanghai First Matern & Infant Hosp, Shanghai Womens Hlth Inst, Shanghai 200092, Peoples R China
|Li, Hong-tian,Trasande, Leonardo,Zhu, Li-ping,et al. Association of cesarean delivery with anemia in infants and children in 2 large longitudinal Chinese birth cohorts[J]. AMERICAN JOURNAL OF CLINICAL NUTRITION,2015,101(3):523-529.|
|APA||Li, Hong-tian,Trasande, Leonardo,Zhu, Li-ping,Ye, Rong-wei,Zhou, Yu-bo,&Liu, Jian-meng.(2015).Association of cesarean delivery with anemia in infants and children in 2 large longitudinal Chinese birth cohorts.AMERICAN JOURNAL OF CLINICAL NUTRITION,101(3),523-529.|
|MLA||Li, Hong-tian,et al."Association of cesarean delivery with anemia in infants and children in 2 large longitudinal Chinese birth cohorts".AMERICAN JOURNAL OF CLINICAL NUTRITION 101.3(2015):523-529.|