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Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats
Wang, Xi; Luo, Yi-xiao; He, Ying-ying; Li, Fang-qiong; Shi, Hai-shui; Xue, Li-fen; Xue, Yan-xue; Lu, Lin
刊名JOURNAL OF NEUROSCIENCE
2010-09-22
DOI10.1523/JNEUROSCI.1264-10.2010
30期:38页:12632-12641
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LONG-TERM POTENTIATION ; VENTRAL TEGMENTAL AREA ; SELF-ADMINISTERED COCAINE ; CONTEXT-INDUCED RELAPSE ; PROTEIN-SYNTHESIS ; DRUG-SEEKING ; BASOLATERAL AMYGDALA ; HEROIN-SEEKING ; TRANSLATIONAL CONTROL ; GLUTAMATE RECEPTORS
英文摘要

Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure to drug-related cues. The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase that regulates cell growth and survival by controlling translation in response to nutrients and growth factors, has been demonstrated to be involved in neuronal adaptations that underlie drug addiction and learning and memory. We investigated the potential role of the mTOR signaling pathway in relapse to cocaine seeking by using the cue-induced reinstatement model in self-administering rats. We found that exposure to a cocaine-related cue induced reinstatement to cocaine seeking and increased phosphorylation of p70s6 kinase (p70s6k) and ribosomal protein s6 (rps6), measures of mTOR activity, in the nucleus accumbens (NAc) core but not shell. Furthermore, inhibition of NAc core but not shell p70s6k and rps6 phosphorylation by rapamycin decreased cue-induced reinstatement of cocaine seeking. Finally, stimulation of NAc core p70s6k and rps6 phosphorylation by NMDA enhanced cue-induced reinstatement, an effect reversed by rapamycin pretreatment. Additionally, rapamycin infusion into the NAc core or shell did not alter ongoing cocaine self-administration or cue-induced reinstatement of sucrose seeking. These findings indicate that cue-induced reinstatement of cocaine seeking is mediated by activation of the mTOR signaling pathway in the NAc core.

语种英语
WOS记录号WOS:000282097600009
项目编号2009CB522004 ; 30725016 ; 09G0762
资助机构National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64898
专题北京大学第三临床医学院_骨科
中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
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Wang, Xi,Luo, Yi-xiao,He, Ying-ying,et al. Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats[J]. JOURNAL OF NEUROSCIENCE,2010,30(38):12632-12641.
APA Wang, Xi.,Luo, Yi-xiao.,He, Ying-ying.,Li, Fang-qiong.,Shi, Hai-shui.,...&Lu, Lin.(2010).Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats.JOURNAL OF NEUROSCIENCE,30(38),12632-12641.
MLA Wang, Xi,et al."Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats".JOURNAL OF NEUROSCIENCE 30.38(2010):12632-12641.
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