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学科主题: 药物依赖
题名:
Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats
作者: Wang, Xi; Luo, Yi-xiao; He, Ying-ying; Li, Fang-qiong; Shi, Hai-shui; Xue, Li-fen; Xue, Yan-xue; Lu, Lin
刊名: JOURNAL OF NEUROSCIENCE
发表日期: 2010-09-22
DOI: 10.1523/JNEUROSCI.1264-10.2010
卷: 30, 期:38, 页:12632-12641
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LONG-TERM POTENTIATION ; VENTRAL TEGMENTAL AREA ; SELF-ADMINISTERED COCAINE ; CONTEXT-INDUCED RELAPSE ; PROTEIN-SYNTHESIS ; DRUG-SEEKING ; BASOLATERAL AMYGDALA ; HEROIN-SEEKING ; TRANSLATIONAL CONTROL ; GLUTAMATE RECEPTORS
英文摘要:

Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure to drug-related cues. The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase that regulates cell growth and survival by controlling translation in response to nutrients and growth factors, has been demonstrated to be involved in neuronal adaptations that underlie drug addiction and learning and memory. We investigated the potential role of the mTOR signaling pathway in relapse to cocaine seeking by using the cue-induced reinstatement model in self-administering rats. We found that exposure to a cocaine-related cue induced reinstatement to cocaine seeking and increased phosphorylation of p70s6 kinase (p70s6k) and ribosomal protein s6 (rps6), measures of mTOR activity, in the nucleus accumbens (NAc) core but not shell. Furthermore, inhibition of NAc core but not shell p70s6k and rps6 phosphorylation by rapamycin decreased cue-induced reinstatement of cocaine seeking. Finally, stimulation of NAc core p70s6k and rps6 phosphorylation by NMDA enhanced cue-induced reinstatement, an effect reversed by rapamycin pretreatment. Additionally, rapamycin infusion into the NAc core or shell did not alter ongoing cocaine self-administration or cue-induced reinstatement of sucrose seeking. These findings indicate that cue-induced reinstatement of cocaine seeking is mediated by activation of the mTOR signaling pathway in the NAc core.

语种: 英语
所属项目编号: 2009CB522004 ; 30725016 ; 09G0762
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000282097600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64898
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xi,Luo, Yi-xiao,He, Ying-ying,et al. Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats[J]. JOURNAL OF NEUROSCIENCE,2010,30(38):12632-12641.
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