学科主题基础医学
Repetition rates of specific interval patterns in single spike train reflect excitation level of specific receptor types, shown by high-speed favored-pattern detection method
Ku, Yun-Hui; Wang, Ming; Li, Yao-Hua; Sun, Ze-Jin; Guo, Tao; Wu, Jin-Sheng
关键词favored pattern unit discharge neural code synaptic transmission
刊名BRAIN RESEARCH
2006-10-03
DOI10.1016/j.brainres.2006.06.119
1113期:1页:110-128
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NUCLEUS PARAGIGANTOCELLULARIS LATERALIS ; ACETYLCHOLINESTERASE-CONTAINING NEURONS ; SPATIOTEMPORAL FIRING PATTERNS ; CORTICOTROPIN-RELEASING-FACTOR ; SUBSTANCE-P ; TOPOGRAPHIC ATLAS ; INFORMATION ; RESPONSES ; ELECTROACUPUNCTURE ; CATECHOLAMINE
英文摘要

Interval patterns in single spike train, e.g. "favored patterns (FPs, the FP is a sequence of successive intervals of action potentials that occur more often than what is reasonably expected at random.)", may represent neural codes containing information. The present study developed a "high-speed FP-detection method" which could qualitatively and quantitatively analyze FPs. By using this method, single spike trains of nucleus paraventricularis (NPV) and rostral ventrolateral medulla (RVL) having different firing patterns, being involved in regulation of arterial pressure, and controlled by different transmitters, were chosen for analysis. Results: (1) Corticotropin releasing factor, substance P and agonists of alpha-, beta- and M-receptor microinjected into these brain areas, respectively, induced dominant change of specific FP. Repetition rates of specific FPs reflect excitation level of specific receptor types. It shows that chemical codes (different transmitters with their receptor types or subtypes) are transformed into electrical codes (different FPs). (2) When alpha-, beta- and M-receptors of RVL neurons were activated simultaneously by intrinsic excitatory transmitters released due to activation of input pathway, only repetition rate of the specific FP that represented the predominant activity of the receptor type (alpha-adrenergic receptor) markedly increased. The activities of other receptor types (beta- and M-receptors) were masked. (3) Intrinsic inhibitory transmitters (GABA, beta-endorphin) in the RVL all decreased specific FP repetition rate of dominant receptor type. These results may provide a new way to further explore how information in the CNS is conveyed and processed. (c) 2006 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000241398500011
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64905
专题北京大学基础医学院_生理学与病理生理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100083, Peoples R China
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GB/T 7714
Ku, Yun-Hui,Wang, Ming,Li, Yao-Hua,et al. Repetition rates of specific interval patterns in single spike train reflect excitation level of specific receptor types, shown by high-speed favored-pattern detection method[J]. BRAIN RESEARCH,2006,1113(1):110-128.
APA Ku, Yun-Hui,Wang, Ming,Li, Yao-Hua,Sun, Ze-Jin,Guo, Tao,&Wu, Jin-Sheng.(2006).Repetition rates of specific interval patterns in single spike train reflect excitation level of specific receptor types, shown by high-speed favored-pattern detection method.BRAIN RESEARCH,1113(1),110-128.
MLA Ku, Yun-Hui,et al."Repetition rates of specific interval patterns in single spike train reflect excitation level of specific receptor types, shown by high-speed favored-pattern detection method".BRAIN RESEARCH 1113.1(2006):110-128.
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